Reactome | FCRL4 [plasma membrane]

FCRL4 [plasma membrane]

Stable Identifier

R-GGA-197802-2

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

FCER1A, A0A8V1AHG1

Locations in the PathwayBrowser

Expand all

Immune System (Gallus gallus)

- Innate Immune System (Gallus gallus)
  - Fc epsilon receptor (FCERI) signaling (Gallus gallus)
    - FCERI mediated Ca+2 mobilization (Gallus gallus)
      - Phosphorylation of TEC kinases by p-SYK (Gallus gallus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI [plasma membrane] (Gallus gallus)
        
        Homologues of FCER1A [plasma membrane] (Gallus gallus)
        
        FCRL4 [plasma membrane] (Gallus gallus)
    - FCERI mediated MAPK activation (Gallus gallus)
      - Phosphorylation of SHC by SYK kinase (Gallus gallus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI [plasma membrane] (Gallus gallus)
        
        Homologues of FCER1A [plasma membrane] (Gallus gallus)
        
        FCRL4 [plasma membrane] (Gallus gallus)
      - Phosphorylation of SLP-76 by p-SYK (Gallus gallus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI [plasma membrane] (Gallus gallus)
        
        Homologues of FCER1A [plasma membrane] (Gallus gallus)
        
        FCRL4 [plasma membrane] (Gallus gallus)
    - FCERI mediated NF-kB activation (Gallus gallus)
      - Phosphorylation of PKC-theta (Gallus gallus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI [plasma membrane] (Gallus gallus)
        
        Homologues of FCER1A [plasma membrane] (Gallus gallus)
        
        FCRL4 [plasma membrane] (Gallus gallus)
    - Recruitment of SYK to p-FCERI gamma subunit (Gallus gallus)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI [plasma membrane] (Gallus gallus)
        
        Homologues of FCER1A [plasma membrane] (Gallus gallus)
        
        FCRL4 [plasma membrane] (Gallus gallus)
      - Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Gallus gallus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI [plasma membrane] (Gallus gallus)
        
        Homologues of FCER1A [plasma membrane] (Gallus gallus)
        
        FCRL4 [plasma membrane] (Gallus gallus)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Gallus gallus)
      - Phosphorylation of NTAL by p-SYK/Lyn (Gallus gallus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI aggregate [plasma membrane] (Gallus gallus)
        
        p-FCERI [plasma membrane] (Gallus gallus)
        
        Homologues of FCER1A [plasma membrane] (Gallus gallus)
        
        FCRL4 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V1AHG1

Gene Names

FCRL4

Reference Genes

BioGPS Gene:425592 FCRL4

ENSEMBL:ENSGALG00010028662.1

Monarch:425592 FCRL4

NCBI Gene:425592 FCRL4

UCSC:A0A8V1AHG1 FCRL4

Reference Transcript

Other Identifiers

425592

GO:0016020

GT_A_87_P032734

Gga.16338.1.S1_s_at

GgaAffx.23243.1.S1_at

Participates

as a member of

Homologues of FCER1A [plasma membrane] (Gallus gallus)

Other forms of this molecule

FCRL4 [extracellular region]

FCRL4 [plasma membrane]

FCRL4 [secretory granule membrane]

FCRL4 [plasma membrane]

FCRL4 [clathrin-coated endocytic vesicle membrane]

FCRL4 [early endosome membrane]

phospho-FCRL4 [plasma membrane]

FCRL4 [plasma membrane]

Inferred From

FCER1A [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_046759882.1, XP_046759881.1, XP_040508271.1

ENSEMBL

ENSGALP00010042761, ENSGALT00010069393, ENSGALG00010028662