Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3

Stable Identifier
R-HSA-195300
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Beta-catenin is then phosphorylated at Ser33. Phosphorylated S37 and S33 together with neighboring residues constitute the recognition motif for beta-TrCP.

Literature References
PubMed ID Title Journal Year
11955436 Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Liu, C, Li, Y, Semenov, M, Han, C, Baeg, GH, Tan, Y, Zhang, Z, Lin, X, He, X

Cell 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created