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CYP51A1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-194721
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
lanosterol 14alpha-demethylase
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
EGR2 and SOX10-mediated initiation of Schwann cell myelination (Homo sapiens)
CYP51A1 gene expression (Homo sapiens)
CYP51A1 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Endogenous sterols (Homo sapiens)
CYP51A1 demethylates LNSOL (Homo sapiens)
CYP51A1 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Cholesterol biosynthesis (Homo sapiens)
CYP51A1 demethylates LNSOL (Homo sapiens)
CYP51A1 [endoplasmic reticulum membrane] (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Lanosterol Demethylase (CYP51A1) (Homo sapiens)
CYP51A1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16850 CYP51A1
Gene Names
CYP51A1, CYP51
Chain
chain:1-509
Reference Genes
BioGPS Gene:1595 CYP51A1
COSMIC (genes):CYP51A1 CYP51A1
CTD Gene:1595 CYP51A1
dbSNP Gene:1595 CYP51A1
ENSEMBL:ENSG00000001630 CYP51A1
ENSEMBL_homo_sapiens_GENE:ENSG00000001630.18 CYP51A1
HGNC:2649 CYP51A1
KEGG Gene (Homo sapiens):1595 CYP51A1
Monarch:1595 CYP51A1
NCBI Gene:1595 CYP51A1
OMIM:601637 CYP51A1
UCSC:Q16850 CYP51A1
Reference Transcript
RefSeq:NM_000786.3 CYP51A1
RefSeq:NM_001146152.1 CYP51A1
Other Identifiers
11722563_x_at
11722564_at
1595
17059628
202314_PM_at
202314_at
216607_PM_s_at
216607_s_at
2684442
2684445
2684446
2684447
2684448
2684449
2684450
2684453
3060998
3060999
3061000
3061001
3061002
3061003
3061004
3061005
3061006
3061007
3061008
3061009
3061010
3061011
3061016
3061017
3061018
3061019
3061020
3061021
33389_at
3507516
3507518
3507519
3507522
3507524
3507526
8140864
8180268
A_23_P257716
GE523206
GE61171
GO:0003824
GO:0004497
GO:0005506
GO:0005783
GO:0005789
GO:0006629
GO:0006694
GO:0006695
GO:0008202
GO:0008203
GO:0008398
GO:0016020
GO:0016125
GO:0016126
GO:0016491
GO:0016705
GO:0020037
GO:0030163
GO:0042177
GO:0043226
GO:0043231
GO:0046872
GO:0050709
GO:1900222
HMNXSV003043512
Hs.226213.1.A1_3p_a_at
ILMN_1664718
PH_hs_0033255
TC07003059.hg
TC07003361.hg
U23942_at
g4503242_3p_at
Participates
as an output of
Expression of Lanosterol Demethylase (CYP51A1) (Homo sapiens)
CYP51A1 gene expression (Homo sapiens)
Inferred To
CYP51A1 [endoplasmic reticulum membrane]
(Bos taurus)
CYP51A1 [endoplasmic reticulum membrane]
(Canis familiaris)
CYP51A1 [endoplasmic reticulum membrane]
(Danio rerio)
CYP51A1 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
CYP51A1 [endoplasmic reticulum membrane]
(Gallus gallus)
CYP51A1 [endoplasmic reticulum membrane]
(Mus musculus)
CYP51A1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
CYP51A1 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
CYP51A1 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
CYP51A1 [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000777.1
,
NP_001139624.1
ZINC - World Drugs
CP51A_HUMAN
Guide to Pharmacology - Targets
1374
OpenTargets
ENSG00000001630
ZINC - FDA approved
CP51A_HUMAN
ZINC - Substances
CP51A_HUMAN
ZINC target
Q16850
PRO
Q16850
PDB
8SBI
,
6Q2T
,
6UEZ
,
4UHL
,
3JUV
,
4UHI
,
3JUS
,
3LD6
,
8SS0
GeneCards
Q16850
HPA
ENSG00000001630-CYP51A1
Ensembl
ENSP00000003100
,
ENSP00000406757
,
ENSG00000001630
,
ENST00000003100
,
ENST00000450723
Pharos - Targets
Q16850
ZINC - Predictions - Purchasable
CP51A_HUMAN
Orphanet
27521
HMDB Protein
HMDBP00265
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96FV3 TSN17
0.527
3
UniProt:O43291 SPINT2
1
SPINT2 [extracellular region]
(R-HSA-6800233)
0.527
3
UniProt:P0CG38 POTEI
0.527
2
UniProt:P01112 HRAS
20
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
0.483
2
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