Reactome | CYP51A1 [endoplasmic reticulum membrane]

CYP51A1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-194721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

lanosterol 14alpha-demethylase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q16850 CYP51A1

Gene Names

CYP51A1, CYP51

Chain

chain:1-509

Reference Genes

BioGPS Gene:1595 CYP51A1

COSMIC (genes):CYP51A1 CYP51A1

CTD Gene:1595 CYP51A1

dbSNP Gene:1595 CYP51A1

ENSEMBL:ENSG00000001630 CYP51A1

HGNC:2649 CYP51A1

KEGG Gene (Homo sapiens):1595 CYP51A1

Monarch:1595 CYP51A1

NCBI Gene:1595 CYP51A1

OMIM:601637 CYP51A1

UCSC:Q16850 CYP51A1

Reference Transcript

Other Identifiers

11722564_at

1595

17059628

216607_PM_s_at

216607_s_at

2684442

2684445

2684446

2684447

2684448

2684449

2684450

2684453

3060999

3061000

3061001

3061002

3061003

3061004

3061005

3061006

3061007

3061008

3061009

3061010

3061011

3061020

3061021

3507518

3507519

3507522

3507524

3507526

8180268

A_23_P257716

GE61171

GO:0003674

GO:0004497

GO:0005506

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0006629

GO:0006694

GO:0006695

GO:0006810

GO:0008150

GO:0008202

GO:0008203

GO:0008398

GO:0009056

GO:0009058

GO:0015031

GO:0016020

GO:0016021

GO:0016125

GO:0016126

GO:0016491

GO:0016705

GO:0020037

GO:0042177

GO:0043167

GO:0043226

GO:0043231

GO:0044281

GO:0046872

GO:0050709

GO:0070988

GO:1900222

Hs.226213.1.A1_3p_a_at

TC07003059.hg

TC07003361.hg

Participates

as an output of

Inferred To

CYP51A1 [endoplasmic reticulum membrane] (Bos taurus)

CYP51A1 [endoplasmic reticulum membrane] (Canis familiaris)

CYP51A1 [endoplasmic reticulum membrane] (Gallus gallus)

CYP51A1 [endoplasmic reticulum membrane] (Sus scrofa)

cyp51 [endoplasmic reticulum membrane] (Danio rerio)

cyp51 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

ERG11 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Cyp51a1 [endoplasmic reticulum membrane] (Mus musculus)

Cyp51a1 [endoplasmic reticulum membrane] (Rattus norvegicus)

erg11 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_000777.1, NP_001139624.1

ZINC - World Drugs

CP51A_HUMAN

Guide to Pharmacology - Targets

1374

OpenTargets

ENSG00000001630

ZINC - FDA approved

CP51A_HUMAN

ZINC - Substances

CP51A_HUMAN

ZINC target

Q16850

PRO

Q16850

PDB

3JUV, 4UHI, 3LD6, 6UEZ, 3JUS, 4UHL, 6Q2T

HPA

ENSG00000001630-CYP51A1

GeneCards

Q16850

Ensembl

ENSG00000001630, ENST00000450723, ENSP00000406757

Pharos - Targets

Q16850

Orphanet

27521

ZINC - Predictions - Purchasable

CP51A_HUMAN

HMDB Protein

HMDBP00265

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.483	2

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