Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol

Stable Identifier
R-HSA-193065
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
22beta-hydroxycholesterol + NADPH + H+ + O2 => 20alpha,22beta-hydroxycholesterol + NADP+ + H2O
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22beta-hydroxycholesterol, NADPH + H+, and O2 react to form 20alpha,22beta-hydroxycholesterol, NADP+ and H2O, catalyzed by CYP11A (P450scc) associated with the inner mitochondrial membrane.

Literature References
PubMed ID Title Journal Year
9578606 Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462

Woods, ST, Sadleir, J, Downs, T, Triantopoulos, T, Headlam, MJ, Tuckey, RC

Arch Biochem Biophys 1998
3024157 Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta

Chung, BC, Matteson, KJ, Voutilainen, R, Mohandas, TK, Miller, WL

Proc Natl Acad Sci U S A 1986
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cholesterol monooxygenase (side-chain-cleaving) activity of CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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