TYSND1 cleaves HSD17B4

Stable Identifier
R-HSA-9033530
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TYSND1 cleaves HSD17B4
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The trypsin-like serine-type endopeptidase TYSND1 cleaves HSD17B4 (Peroxisomal multifunctional enzyme type 2, MFP-2) between amino acid residues 311 and 312, yielding HSD17B4(1-311) and HSD17B4(312-736) (Okumoto et al. 2011, also inferred from mouse homologs). HSD17B4(1-311) dehydrogenates 3-hydroxyacyl-CoA; HSD17B4(312-736) acts as an enoyl-CoA hydratase (Jiang et al. 1997, reviewed in Huyghe et al. 2006). (In vitro, HSD17B4(312-736) facilitates the transfer of 7-dehydrocholesterol and phosphatidylcholine between membranes.) The uncleaved protein (HSD17B4) also catalyzes these reactions.
Literature References
PubMed ID Title Journal Year
22002062 Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix

Kametani, Y, Okumoto, K, Fujiki, Y

J. Biol. Chem. 2011
9089413 Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein

Souri, M, Hashimoto, T, Jiang, LL, Miyazawa, S

J Biochem 1997
16766224 Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model

Baes, M, Van Veldhoven, PP, Huyghe, S, Mannaerts, GP

Biochim Biophys Acta 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of TYSND1 [peroxisomal matrix]

Physical Entity
TYSND1 [peroxisomal matrix] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
Tysnd1 cleaves Hsd17b4 (Mus musculus)
Authored
May, B  (2017-12-22)
Reviewed
Van Veldhoven, PP  (2018-02-13)
Fransen, M  (2018-02-13)
Azevedo, JE  (2018-03-12)
Created
May, B  (2017-12-22)
Cite Us!