TYSND1 cleaves HSD17B4

Stable Identifier
R-HSA-9033530
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
ReviewStatus
5/5
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TYSND1 cleaves HSD17B4
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The trypsin-like serine-type endopeptidase TYSND1 cleaves HSD17B4 (Peroxisomal multifunctional enzyme type 2, MFP-2) between amino acid residues 311 and 312, yielding HSD17B4(1-311) and HSD17B4(312-736) (Okumoto et al. 2011, also inferred from mouse homologs). HSD17B4(1-311) dehydrogenates 3-hydroxyacyl-CoA; HSD17B4(312-736) acts as an enoyl-CoA hydratase (Jiang et al. 1997, reviewed in Huyghe et al. 2006). (In vitro, HSD17B4(312-736) facilitates the transfer of 7-dehydrocholesterol and phosphatidylcholine between membranes.) The uncleaved protein (HSD17B4) also catalyzes these reactions.
Literature References
PubMed ID Title Journal Year
22002062 Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix

Okumoto, K, Kametani, Y, Fujiki, Y

J. Biol. Chem. 2011
9089413 Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein

Jiang, LL, Miyazawa, S, Souri, M, Hashimoto, T

J Biochem 1997
16766224 Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model

Huyghe, S, Mannaerts, GP, Baes, M, Van Veldhoven, PP

Biochim Biophys Acta 2006
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Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of TYSND1 [peroxisomal matrix]

Physical Entity
TYSND1 [peroxisomal matrix] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
Tysnd1 cleaves Hsd17b4 (Mus musculus)
Authored
May, B  (2017-12-22)
Reviewed
Fransen, M  (2018-02-13)
Van Veldhoven, PP  (2018-02-13)
Azevedo, JE  (2018-03-12)
Created
May, B  (2017-12-22)
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