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Gap junction assembly
Stable Identifier
R-HSA-190861
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Gap junction trafficking and regulation (Homo sapiens)
Gap junction trafficking (Homo sapiens)
Gap junction assembly (Homo sapiens)
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The assembly of gap junctions involves (1) synthesis of connexin polypeptides at endoplasmic reticulum membranes, (2) oligomerization into homomeric- and heteromeric gap junction connexons (hemi-channels), (3) passage through the Golgi stacks, (4) intracellular storage within Trans Golgi membranes, (5) trafficking along microtubules, (6) insertion of connexons into the plasma membrane, (7) lateral diffusion of connexons in the plasma membrane, (8) aggregation of individual gap junction channels into plaques, and (9) stabilization of peripheral microtubule plus-ends by binding to Cx43-based gap junctions (see Segretain and Falk, 2004.)
Literature References
PubMed ID
Title
Journal
Year
15033576
Regulation of connexin biosynthesis, assembly, gap junction formation, and removal
Segretain, D
,
Falk, MM
Biochim Biophys Acta
2004
8665925
Connections with connexins: the molecular basis of direct intercellular signaling
Bruzzone, R
,
White, TW
,
Paul, DL
Eur J Biochem
1996
Participants
Events
Connexin synthesis (generic)
(Homo sapiens)
Synthesis of Cx26
(Homo sapiens)
Synthesis of GJB1 (Cx32)
(Homo sapiens)
Synthesis of Cx43
(Homo sapiens)
Transport of connexins along the secretory pathway
(Homo sapiens)
Oligomerization of connexins into connexons
(Homo sapiens)
Transport of connexons to the plasma membrane
(Homo sapiens)
Docking of connexons into junctional, double-membrane spanning channels
(Homo sapiens)
Insertion of connexons into the plasma membrane resulting in the formation of hemi-channels
(Homo sapiens)
Formation of junctional channels
(Homo sapiens)
Assembly of gap junction plaques
(Homo sapiens)
Participates
as an event of
Gap junction trafficking (Homo sapiens)
Event Information
Go Biological Process
gap junction assembly (0016264)
Orthologous Events
Gap junction assembly (Bos taurus)
Gap junction assembly (Canis familiaris)
Gap junction assembly (Danio rerio)
Gap junction assembly (Gallus gallus)
Gap junction assembly (Mus musculus)
Gap junction assembly (Rattus norvegicus)
Gap junction assembly (Sus scrofa)
Gap junction assembly (Xenopus tropicalis)
Authored
Gilleron, J (2007-01-03)
Segretain, D (2007-01-03)
Falk, MM (2007-01-03)
Created
Matthews, L (2007-01-09)
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