Transport of connexons to the plasma membrane

Stable Identifier
R-HSA-190872
Type
Pathway
Species
Homo sapiens
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Following connexon oligomerization, the hemichannels must be transported to the plasma membrane. This has been shown to occur in transport vesicles called "cargo containers". Most of post-Golgi cargo containers have a diameter of of 50- 200 nm (Lauf et al., 2002). Recently direct transport of connexins to GJ assembly sides has been described (Shaw et al., 2007). Besides microtuble-dependent trafficking, a microtubule-independent delivery pathway may exist as concluded from studies using the secretory transport inhibitor, Brefeldin A (Musil and Goodenough 1993; De Sousa et al. 1993; Laird et al. 1995).

Literature References
PubMed ID Title Journal Year
17289573 Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions

Shaw, RM, Fay, AJ, Puthenveedu, MA, von Zastrow, M, Jan, YN, Jan, LY

Cell 2007
7691412 Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER

Musil, LS, Goodenough, DA

Cell 1993
12149451 Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells

Lauf, U, Giepmans, BN, Lopez, P, Braconnot, S, Chen, SC, Falk, MM

Proc Natl Acad Sci U S A 2002
8404537 Connexin trafficking and the control of gap junction assembly in mouse preimplantation embryos

De Sousa, PA, Valdimarsson, G, Nicholson, BJ, Kidder, GM

Development 1993
8522583 Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells

Laird, DW, Castillo, M, Kasprzak, L

J Cell Biol 1995
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