Reactome | Transport of connexons to the plasma membrane

Transport of connexons to the plasma membrane

Stable Identifier

R-HSA-190872

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Transport of connexons to the plasma membrane

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Following connexon oligomerization, the hemichannels must be transported to the plasma membrane. This has been shown to occur in transport vesicles called "cargo containers". Most of post-Golgi cargo containers have a diameter of of 50- 200 nm (Lauf et al., 2002). Recently direct transport of connexins to GJ assembly sides has been described (Shaw et al., 2007). Besides microtuble-dependent trafficking, a microtubule-independent delivery pathway may exist as concluded from studies using the secretory transport inhibitor, Brefeldin A (Musil and Goodenough 1993; De Sousa et al. 1993; Laird et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
7691412	Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER Musil, LS, Goodenough, DA	Cell	1993
17289573	Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions Shaw, RM, Fay, AJ, Puthenveedu, MA, von Zastrow, M, Jan, YN, Jan, LY	Cell	2007
12149451	Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells Lauf, U, Giepmans, BN, Lopez, P, Braconnot, S, Chen, SC, Falk, MM	Proc Natl Acad Sci U S A	2002
8404537	Connexin trafficking and the control of gap junction assembly in mouse preimplantation embryos De Sousa, PA, Valdimarsson, G, Nicholson, BJ, Kidder, GM	Development	1993
8522583	Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells Laird, DW, Castillo, M, Kasprzak, L	J Cell Biol	1995