Assembly of gap junction plaques

Stable Identifier
R-HSA-190790
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once transported to the plasma membrane, junctional channels aggregate into clusters forming gap junction plaques that may contain a few to many thousands of individual channels and that vary in size from a few square nanometers to many square micrometers (Bruzzone et al. 1996; Falk 2000; Severs et al. 2001). Gap junction plaques are involved in numerous processes including growth and differentiation (Loewenstein and Rose 1992), pathological cell proliferation (Roger et al. 2004; Segretain et al. 2003) and spermatogenesis (Juneja et al. 1999; Plum et al. 2000). The physiological importance of gap junction plaques is underscored by the diverse pathologies associated with connexin gene mutations (De Maio et al. 2002). An arbitrary number (10) of channels is shown as aggregating in this reaction but the actual number may be hundreds to thousands.

Literature References
PubMed ID Title Journal Year
17200141 Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis

Wang, M, Berthoud, VM, Beyer, EC

J Cell Sci 2007
Participants
Participant Of
Authored
Created