Reactome | COMT [plasma membrane]

COMT [plasma membrane]

Stable Identifier

R-HSA-379386

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Catechol O-methyltransferase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P21964 COMT

Gene Names

COMT

Chain

chain:1-271

Reference Genes

BioGPS Gene:1312 COMT

COSMIC (genes):COMT COMT

CTD Gene:1312 COMT

dbSNP Gene:1312 COMT

ENSEMBL:ENSG00000093010 COMT

ENSEMBL_homo_sapiens_GENE:ENSG00000093010.15 COMT

HGNC:2228 COMT

KEGG Gene (Homo sapiens):1312 COMT

Monarch:1312 COMT

NCBI Gene:1312 COMT

UCSC:P21964 COMT

Reference Transcript

Other Identifiers

11716447_s_at

11734871_s_at

11734872_x_at

11754132_x_at

1312

208817_PM_at

208817_at

208818_PM_s_at

208818_s_at

213981_PM_at

213981_at

236671_PM_at

236671_at

34651_at

3937095

3937096

3937101

3937103

3937107

3937108

3937109

3937110

3937111

3937112

3937113

3937114

3937116

3937121

3937122

3937123

8071289

A_23_P251680

GE80950

GE88255

GO:0000287

GO:0001662

GO:0001666

GO:0001822

GO:0001963

GO:0001964

GO:0001975

GO:0002001

GO:0003013

GO:0003014

GO:0003824

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005886

GO:0005975

GO:0005977

GO:0006091

GO:0006584

GO:0006629

GO:0006693

GO:0006979

GO:0007611

GO:0007612

GO:0007613

GO:0008168

GO:0008171

GO:0008217

GO:0008542

GO:0009266

GO:0009410

GO:0009611

GO:0009636

GO:0010033

GO:0010035

GO:0010467

GO:0014046

GO:0016020

GO:0016036

GO:0016206

GO:0016740

GO:0021696

GO:0022600

GO:0023052

GO:0030424

GO:0030425

GO:0031982

GO:0032094

GO:0032259

GO:0032502

GO:0032835

GO:0033344

GO:0033555

GO:0034097

GO:0035264

GO:0035640

GO:0035812

GO:0042415

GO:0042417

GO:0042420

GO:0042424

GO:0042596

GO:0043226

GO:0043231

GO:0045202

GO:0046872

GO:0046959

GO:0048243

GO:0048856

GO:0050877

GO:0050886

GO:0050890

GO:0050965

GO:0051412

GO:0055065

GO:0060840

GO:0070062

GO:0071314

GO:0071626

GO:0097018

GO:0097205

GO:0102084

GO:0102938

GO:1902074

GO:1903350

GO:1990776

HMNXSV003041495

Hs.132238.0.A1_3p_at

Hs.240013.1.A1_3p_at

ILMN_1730084

ILMN_1810941

M58525_s_at

TC22000050.hg

TC22000966.hg

Z26491_s_at

g12653300_3p_a_at

p33877

Participates

as a component of

COMT:COMT inhibitors [plasma membrane] (Homo sapiens)

as an input of

COMT binds COMT Inhibitors (Homo sapiens)

Other forms of this molecule

COMT [cytosol]

Inferred To

COMT [plasma membrane] (Bos taurus)

COMT [plasma membrane] (Canis familiaris)

COMT [plasma membrane] (Danio rerio)

COMT [plasma membrane] (Gallus gallus)

COMT [plasma membrane] (Mus musculus)

COMT [plasma membrane] (Rattus norvegicus)

COMT [plasma membrane] (Schizosaccharomyces pombe)

COMT [plasma membrane] (Sus scrofa)

COMT [plasma membrane] (Xenopus tropicalis)

Homologues of COMT [plasma membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_000745.1, NP_001128633.1, XP_016884084.1, NP_001128634.1, NP_009294.1, XP_016884083.1

ZINC - World Drugs

COMT_HUMAN

Guide to Pharmacology - Targets

2472

OpenTargets

ENSG00000093010

ZINC - Substances

COMT_HUMAN

ZINC target

P21964

PRO

P21964

PDB

3A7E, 6I3D, 3BWM, 6I3C, 5LSA, 4XUC, 4PYJ, 4PYK, 4XUD, 4XUE, 4PYI, 3BWY

HPA

ENSG00000093010-COMT

GeneCards

P21964

Ensembl

ENST00000407537, ENSP00000354511, ENSP00000384654, ENST00000449653, ENSP00000503719, ENSP00000385917, ENSP00000503583, ENST00000678255, ENST00000403710, ENSP00000504402, ENST00000676678, ENST00000361682, ENSG00000093010, ENST00000406520, ENSP00000385150, ENST00000678868, ENSP00000416778

Pharos - Targets

P21964

Orphanet

19456

ZINC - Predictions - Purchasable

COMT_HUMAN

HMDB Protein

HMDBP00272

Interactors (60)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6UW68 TM205			0.666	4
UniProt:Q15645 PCH2			0.621	3
UniProt:Q9NTQ9 GJB4	1	GJB4 [endoplasmic reticulum membrane] (R-HSA-190624)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9NY26 SLC39A1	1	SLC39A1 [plasma membrane] (R-HSA-442329)	0.556	3
UniProt:Q5T1Q4 S35F1			0.556	3
UniProt:O95183 VAMP5			0.556	3
UniProt:O00258 GET1	1	WRB [endoplasmic reticulum membrane] (R-HSA-9609521)	0.556	3
UniProt:B2RUZ4 SMIM1			0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:Q9UHJ9-5 PGAP2			0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:O60669 SLC16A7	1	SLC16A7 [plasma membrane] (R-HSA-373955)	0.556	3
UniProt:Q6P5T0 Q6P5T0			0.556	3
UniProt:O95377 GJB5	1	GJB5 [endoplasmic reticulum membrane] (R-HSA-190643)	0.556	3
UniProt:O75783 RHBL1			0.556	3
UniProt:Q6NTF9-3 Q6NTF93			0.556	3
UniProt:Q9H6H4 REEP4			0.556	3
UniProt:Q9NP94 SLC39A2	1	SLC39A2 [plasma membrane] (R-HSA-442395)	0.556	3
UniProt:Q7RTS5 OTOP3			0.556	3
UniProt:Q9UHI5 SLC7A8	1	SLC7A8 [plasma membrane] (R-HSA-352156)	0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.556	3
UniProt:P31937 HIBADH	1	HIBADH [mitochondrial matrix] (R-HSA-70882)	0.556	3
UniProt:Q96G79 S35A4			0.556	3
UniProt:Q9H0R3 TM222			0.556	3
UniProt:Q6P1K1 HRG1			0.556	3
UniProt:A0PK00 T120B			0.556	3
UniProt:Q9NV29 TM100			0.556	3
UniProt:P34972 CNR2	1	CNR2 [plasma membrane] (R-HSA-419372)	0.556	3
UniProt:O75712 GJB3	2	GJB3 [plasma membrane] (R-HSA-9839595) GJB3 [endoplasmic reticulum membrane] (R-HSA-190625)	0.556	3
UniProt:Q8NHW4 CCL4L1	1	CCL4L1 [extracellular region] (R-HSA-8865389)	0.556	3
UniProt:O95807 TM50A			0.556	3
UniProt:A6NDP7 MADL2			0.556	3
UniProt:Q9UPZ6 THSD7A	3	THSD7A [endoplasmic reticulum lumen] (R-HSA-5173009) glc-fuc-THSD7A [endoplasmic reticulum lumen] (R-HSA-5173197) O-fuc-THSD7A [endoplasmic reticulum lumen] (R-HSA-5173184)	0.556	3
UniProt:Q9NUH8 TM14B			0.556	3
UniProt:O15529 GPR42			0.556	3
UniProt:Q0D2K0 NIPAL4	1	NIPAL4 [plasma membrane] (R-HSA-5216046)	0.556	3
UniProt:Q5SR56 MF14B			0.556	3
UniProt:Q9Y6D0 SELK			0.556	3
UniProt:Q9P0S9 TM14C			0.556	3
UniProt:O95279 KCNK5	1	KCNK5 [plasma membrane] (R-HSA-1296323)	0.556	3
UniProt:Q96MV1 TLCD4			0.556	3
UniProt:Q8NFU1 BEST2	1	BEST2 [plasma membrane] (R-HSA-2744359)	0.556	3
UniProt:Q8N6U8 GPR161	2	GPR161 [endocytic vesicle membrane] (R-HSA-5635021) GPR161 [ciliary membrane] (R-HSA-5610373)	0.556	3
UniProt:Q14656 TM187			0.556	3
UniProt:P22732 SLC2A5	2	SLC2A5 [plasma membrane] (R-HSA-189202) SLC2A5 [specific granule membrane] (R-HSA-6799571)	0.556	3
UniProt:O14843 FFAR3	1	FFAR3 [plasma membrane] (R-HSA-443951)	0.556	3
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.556	3
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.556	3
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.556	3
UniProt:Q99500 S1PR3	1	S1PR3 [plasma membrane] (R-HSA-419396)	0.556	3
UniProt:P30518 AVPR2	3	AVPR2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869077) p-AVPR2 [plasma membrane] (R-HSA-8866009) AVPR2 [plasma membrane] (R-HSA-388431)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:P08034 GJB1	2	GJB1 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190636) GJB1 [endoplasmic reticulum membrane] (R-HSA-190656)	0.556	3
UniProt:P34981 TRHR	1	TRHR [plasma membrane] (R-HSA-444556)	0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:P0DTD1-PRO_0000449625 REP			0.527	2
UniProt:P0DTD8 NS7B			0.527	2
UniProt:P12520 VPR			0.462	2

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