The reversible transport of extracellular fructose into the cytosol is mediated by SLC2A5, also known as GLUT5. In the small intestine, SLC2A5 is localized on the lumenal surfaces of enterocytes (Davidson et al. 1992) and mediates the uptake of dietary fructose, which can be released into the circulation in a separate transport step mediated by basolaterally localized SLC2A2 (GLUT2). The specificity of SLC2A5 has been worked out by studying sugar transport in Xenopus oocytes expressing recombinant human SLC2A5 protein (Burant et al. 1992).
Buse, JB, Gould, GW, Burant, CF, Bell, GI, Davidson, NO, Hausman, AM, Ifkovits, CA
Burant, CF, Takeda, J, Davidson, NO, Bell, GI, Brot-Laroche, E
fructose transmembrane transporter activity of SLC2A5 [plasma membrane]
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