Reactome | SLC2A5 transports fructose from extracellular region to cytosol

SLC2A5 transports fructose from extracellular region to cytosol

Stable Identifier

R-HSA-189222

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Transport (influx) of fructose by GLUT5, extracellular fructose => cytosolic fructose

ReviewStatus

5/5

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SLC2A5 transports fructose from extracellular region to cytosol

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The reversible transport of extracellular fructose into the cytosol is mediated by SLC2A5, also known as GLUT5. In the small intestine, SLC2A5 is localized on the lumenal surfaces of enterocytes (Davidson et al. 1992) and mediates the uptake of dietary fructose, which can be released into the circulation in a separate transport step mediated by basolaterally localized SLC2A2 (GLUT2). The specificity of SLC2A5 has been worked out by studying sugar transport in Xenopus oocytes expressing recombinant human SLC2A5 protein (Burant et al. 1992).

Literature References

PubMed ID	Title	Journal	Year
1550217	Human intestinal glucose transporter expression and localization of GLUT5 Davidson, NO, Hausman, AM, Ifkovits, CA, Buse, JB, Gould, GW, Burant, CF, Bell, GI	Am J Physiol	1992
1634504	Fructose transporter in human spermatozoa and small intestine is GLUT5 Burant, CF, Takeda, J, Brot-Laroche, E, Bell, GI, Davidson, NO	J Biol Chem	1992