SLC2A5 transports fructose from extracellular region to cytosol

Stable Identifier
R-HSA-189222
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Transport (influx) of fructose by GLUT5, extracellular fructose => cytosolic fructose
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The reversible transport of extracellular fructose into the cytosol is mediated by SLC2A5, also known as GLUT5. In the small intestine, SLC2A5 is localized on the lumenal surfaces of enterocytes (Davidson et al. 1992) and mediates the uptake of dietary fructose, which can be released into the circulation in a separate transport step mediated by basolaterally localized SLC2A2 (GLUT2). The specificity of SLC2A5 has been worked out by studying sugar transport in Xenopus oocytes expressing recombinant human SLC2A5 protein (Burant et al. 1992).

Literature References
PubMed ID Title Journal Year
1634504 Fructose transporter in human spermatozoa and small intestine is GLUT5

Burant, CF, Takeda, J, Brot-Laroche, E, Bell, GI, Davidson, NO

J Biol Chem 1992
1550217 Human intestinal glucose transporter expression and localization of GLUT5

Davidson, NO, Hausman, AM, Ifkovits, CA, Buse, JB, Gould, GW, Burant, CF, Bell, GI

Am J Physiol 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
fructose transmembrane transporter activity of SLC2A5 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created
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