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Fru [cytosol]
Stable Identifier
R-ALL-29532
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Levulose, D-fructose, Fruit sugar, D-Arabino-hexulose
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Sus scrofa
Xenopus tropicalis
Expand all
Digestion and absorption (Bos taurus)
Intestinal absorption (Bos taurus)
Intestinal hexose absorption (Bos taurus)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Bos taurus)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Bos taurus)
Fru [cytosol]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
Cytochrome P450 - arranged by substrate type (Bos taurus)
Vitamins (Bos taurus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
Fru [cytosol]
Metabolism of lipids (Bos taurus)
Metabolism of steroids (Bos taurus)
Vitamin D (calciferol) metabolism (Bos taurus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)
Fru [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
Fru [cytosol]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Cellular hexose transport (Bos taurus)
GLUT7 and GLUT11 transport glucose and fructose (Bos taurus)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Bos taurus)
Fru,Glc,urate [cytosol]
Fru [cytosol]
SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Bos taurus)
Fru, Man [cytosol]
Fru [cytosol]
Digestion and absorption (Caenorhabditis elegans)
Intestinal absorption (Caenorhabditis elegans)
Intestinal hexose absorption (Caenorhabditis elegans)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Caenorhabditis elegans)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Caenorhabditis elegans)
Fru [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Metabolism of steroids (Caenorhabditis elegans)
Vitamin D (calciferol) metabolism (Caenorhabditis elegans)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Caenorhabditis elegans)
Fru [cytosol]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Cellular hexose transport (Caenorhabditis elegans)
GLUT7 and GLUT11 transport glucose and fructose (Caenorhabditis elegans)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Caenorhabditis elegans)
Fru,Glc,urate [cytosol]
Fru [cytosol]
Digestion and absorption (Canis familiaris)
Intestinal absorption (Canis familiaris)
Intestinal hexose absorption (Canis familiaris)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Canis familiaris)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Canis familiaris)
Fru [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
Cytochrome P450 - arranged by substrate type (Canis familiaris)
Vitamins (Canis familiaris)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
Fru [cytosol]
Metabolism of lipids (Canis familiaris)
Metabolism of steroids (Canis familiaris)
Vitamin D (calciferol) metabolism (Canis familiaris)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)
Fru [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
Fru [cytosol]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Cellular hexose transport (Canis familiaris)
GLUT7 and GLUT11 transport glucose and fructose (Canis familiaris)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Canis familiaris)
Fru,Glc,urate [cytosol]
Fru [cytosol]
SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Canis familiaris)
Fru, Man [cytosol]
Fru [cytosol]
Digestion and absorption (Danio rerio)
Intestinal absorption (Danio rerio)
Intestinal hexose absorption (Danio rerio)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Danio rerio)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Danio rerio)
Fru [cytosol]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Phase I - Functionalization of compounds (Danio rerio)
Cytochrome P450 - arranged by substrate type (Danio rerio)
Vitamins (Danio rerio)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
Fru [cytosol]
Metabolism of lipids (Danio rerio)
Metabolism of steroids (Danio rerio)
Vitamin D (calciferol) metabolism (Danio rerio)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)
Fru [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
Fru [cytosol]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Cellular hexose transport (Danio rerio)
GLUT7 and GLUT11 transport glucose and fructose (Danio rerio)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Danio rerio)
Fru,Glc,urate [cytosol]
Fru [cytosol]
Digestion and absorption (Dictyostelium discoideum)
Intestinal absorption (Dictyostelium discoideum)
Intestinal hexose absorption (Dictyostelium discoideum)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Dictyostelium discoideum)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Dictyostelium discoideum)
Fru [cytosol]
Transport of small molecules (Dictyostelium discoideum)
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Cellular hexose transport (Dictyostelium discoideum)
GLUT7 and GLUT11 transport glucose and fructose (Dictyostelium discoideum)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Dictyostelium discoideum)
Fru,Glc,urate [cytosol]
Fru [cytosol]
Digestion and absorption (Drosophila melanogaster)
Intestinal absorption (Drosophila melanogaster)
Intestinal hexose absorption (Drosophila melanogaster)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Drosophila melanogaster)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Drosophila melanogaster)
Fru [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Metabolism of steroids (Drosophila melanogaster)
Vitamin D (calciferol) metabolism (Drosophila melanogaster)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Drosophila melanogaster)
Fru [cytosol]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Cellular hexose transport (Drosophila melanogaster)
GLUT7 and GLUT11 transport glucose and fructose (Drosophila melanogaster)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Drosophila melanogaster)
Fru,Glc,urate [cytosol]
Fru [cytosol]
Digestion and absorption (Gallus gallus)
Intestinal absorption (Gallus gallus)
Intestinal hexose absorption (Gallus gallus)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Gallus gallus)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Gallus gallus)
Fru [cytosol]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Cellular hexose transport (Gallus gallus)
GLUT7 and GLUT11 transport glucose and fructose (Gallus gallus)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Gallus gallus)
Fru,Glc,urate [cytosol]
Fru [cytosol]
SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Gallus gallus)
Fru, Man [cytosol]
Fru [cytosol]
Digestion and absorption (Homo sapiens)
Intestinal absorption (Homo sapiens)
Intestinal hexose absorption (Homo sapiens)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Homo sapiens)
Fru [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of carbohydrate metabolism (Homo sapiens)
Essential fructosuria (Homo sapiens)
Defective KHK does not phosphorylate beta-D-fructose (Homo sapiens)
Fru [cytosol]
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) (Homo sapiens)
Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Vitamins (Homo sapiens)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)
Fru [cytosol]
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Vitamin D (calciferol) metabolism (Homo sapiens)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Homo sapiens)
Fru [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)
Fru [cytosol]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Cellular hexose transport (Homo sapiens)
GLUT7 and GLUT11 transport glucose and fructose (Homo sapiens)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Homo sapiens)
Fru,Glc,urate [cytosol]
Fru [cytosol]
SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Homo sapiens)
Fru, Man [cytosol]
Fru [cytosol]
Digestion and absorption (Mus musculus)
Intestinal absorption (Mus musculus)
Intestinal hexose absorption (Mus musculus)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Mus musculus)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Mus musculus)
Fru [cytosol]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase I - Functionalization of compounds (Mus musculus)
Cytochrome P450 - arranged by substrate type (Mus musculus)
Vitamins (Mus musculus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)
Fru [cytosol]
Metabolism of lipids (Mus musculus)
Metabolism of steroids (Mus musculus)
Vitamin D (calciferol) metabolism (Mus musculus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Mus musculus)
Fru [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)
Fru [cytosol]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Cellular hexose transport (Mus musculus)
GLUT7 and GLUT11 transport glucose and fructose (Mus musculus)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Mus musculus)
Fru,Glc,urate [cytosol]
Fru [cytosol]
SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Mus musculus)
Fru, Man [cytosol]
Fru [cytosol]
Digestion and absorption (Plasmodium falciparum)
Intestinal absorption (Plasmodium falciparum)
Intestinal hexose absorption (Plasmodium falciparum)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Plasmodium falciparum)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Plasmodium falciparum)
Fru [cytosol]
Transport of small molecules (Plasmodium falciparum)
SLC-mediated transmembrane transport (Plasmodium falciparum)
Cellular hexose transport (Plasmodium falciparum)
GLUT7 and GLUT11 transport glucose and fructose (Plasmodium falciparum)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Plasmodium falciparum)
Fru,Glc,urate [cytosol]
Fru [cytosol]
Digestion and absorption (Rattus norvegicus)
Intestinal absorption (Rattus norvegicus)
Intestinal hexose absorption (Rattus norvegicus)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Rattus norvegicus)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Rattus norvegicus)
Fru [cytosol]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase I - Functionalization of compounds (Rattus norvegicus)
Cytochrome P450 - arranged by substrate type (Rattus norvegicus)
Vitamins (Rattus norvegicus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)
Fru [cytosol]
Metabolism of lipids (Rattus norvegicus)
Metabolism of steroids (Rattus norvegicus)
Vitamin D (calciferol) metabolism (Rattus norvegicus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Rattus norvegicus)
Fru [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)
Fru [cytosol]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Cellular hexose transport (Rattus norvegicus)
GLUT7 and GLUT11 transport glucose and fructose (Rattus norvegicus)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Rattus norvegicus)
Fru,Glc,urate [cytosol]
Fru [cytosol]
SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Rattus norvegicus)
Fru, Man [cytosol]
Fru [cytosol]
Digestion and absorption (Saccharomyces cerevisiae)
Intestinal absorption (Saccharomyces cerevisiae)
Intestinal hexose absorption (Saccharomyces cerevisiae)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Saccharomyces cerevisiae)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Saccharomyces cerevisiae)
Fru [cytosol]
Transport of small molecules (Saccharomyces cerevisiae)
SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
Cellular hexose transport (Saccharomyces cerevisiae)
GLUT7 and GLUT11 transport glucose and fructose (Saccharomyces cerevisiae)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Saccharomyces cerevisiae)
Fru,Glc,urate [cytosol]
Fru [cytosol]
Digestion and absorption (Sus scrofa)
Intestinal absorption (Sus scrofa)
Intestinal hexose absorption (Sus scrofa)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Sus scrofa)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Sus scrofa)
Fru [cytosol]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase I - Functionalization of compounds (Sus scrofa)
Cytochrome P450 - arranged by substrate type (Sus scrofa)
Vitamins (Sus scrofa)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)
Fru [cytosol]
Metabolism of lipids (Sus scrofa)
Metabolism of steroids (Sus scrofa)
Vitamin D (calciferol) metabolism (Sus scrofa)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Sus scrofa)
Fru [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)
Fru [cytosol]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Cellular hexose transport (Sus scrofa)
GLUT7 and GLUT11 transport glucose and fructose (Sus scrofa)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Sus scrofa)
Fru,Glc,urate [cytosol]
Fru [cytosol]
SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Sus scrofa)
Fru, Man [cytosol]
Fru [cytosol]
Digestion and absorption (Xenopus tropicalis)
Intestinal absorption (Xenopus tropicalis)
Intestinal hexose absorption (Xenopus tropicalis)
SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Xenopus tropicalis)
Fru, Gal, Glc [cytosol]
Fru [cytosol]
SLC2A5 transports fructose from extracellular region to cytosol (Xenopus tropicalis)
Fru [cytosol]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Cellular hexose transport (Xenopus tropicalis)
GLUT7 and GLUT11 transport glucose and fructose (Xenopus tropicalis)
hexoses transported by GLUT7/11 [cytosol]
Fru [cytosol]
SLC2A9 transports Fru, Glc, urate (Xenopus tropicalis)
Fru,Glc,urate [cytosol]
Fru [cytosol]
SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Xenopus tropicalis)
Fru, Man [cytosol]
Fru [cytosol]
External Reference Information
External Reference
D-fructose [ChEBI:15824]
Participates
as an input of
Defective KHK does not phosphorylate beta-D-fructose (Homo sapiens)
as a member of
Fru, Gal, Glc [cytosol]
Fru, Man [cytosol]
hexoses transported by GLUT7/11 [cytosol]
Fru,Glc,urate [cytosol]
as an output of
SLC2A5 transports fructose from extracellular region to cytosol (Plasmodium falciparum)
SLC2A5 transports fructose from extracellular region to cytosol (Saccharomyces cerevisiae)
SLC2A5 transports fructose from extracellular region to cytosol (Dictyostelium discoideum)
SLC2A5 transports fructose from extracellular region to cytosol (Caenorhabditis elegans)
SLC2A5 transports fructose from extracellular region to cytosol (Drosophila melanogaster)
SLC2A5 transports fructose from extracellular region to cytosol (Gallus gallus)
SLC2A5 transports fructose from extracellular region to cytosol (Xenopus tropicalis)
SLC2A5 transports fructose from extracellular region to cytosol (Danio rerio)
SLC2A5 transports fructose from extracellular region to cytosol (Sus scrofa)
SLC2A5 transports fructose from extracellular region to cytosol (Bos taurus)
SLC2A5 transports fructose from extracellular region to cytosol (Canis familiaris)
SLC2A5 transports fructose from extracellular region to cytosol (Rattus norvegicus)
SLC2A5 transports fructose from extracellular region to cytosol (Mus musculus)
SLC2A5 transports fructose from extracellular region to cytosol (Homo sapiens)
This entity regulates
Negatively
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
(Sus scrofa)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
(Bos taurus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
(Canis familiaris)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
(Rattus norvegicus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
(Mus musculus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
(Homo sapiens)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
(Danio rerio)
Positively
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
(Caenorhabditis elegans)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
(Drosophila melanogaster)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
(Sus scrofa)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
(Bos taurus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
(Canis familiaris)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
(Rattus norvegicus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
(Mus musculus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
(Homo sapiens)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
(Danio rerio)
Other forms of this molecule
Fru [extracellular region]
Cross References
Guide to Pharmacology - Ligands
4654
COMPOUND
C00095
,
C10906
PubChem Substance
8145406
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