Reactome | Intestinal hexose absorption

Intestinal hexose absorption

Stable Identifier

R-HSA-8981373

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

Hexoses, notably fructose, glucose, and galactose generated in the lumen of the small intestine by breakdown of dietary carbohydrate, are taken up by enterocytes lining the microvilli of the small intestine and released from them into the blood. Uptake into enterocytes is mediated by two transporters localized on the luminal surfaces of the cells. SLC5A1, also known as SGLT1, mediates the co-transport of sodium ions and glucose and galactose, and SLC2A5, also known as GLUT5, mediates fructose uptake (Wright 1998). Tetrameric SLC2A2, also known as GLUT2, localized on the basolateral surfaces of enterocytes, mediates the release of these hexoses into the blood (Kellett & Brot-Laroche 2005; Wright et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
9815014	Genetic Disorders of Membrane Transport I. Glucose galactose malabsorption Wright, EM	Am. J. Physiol.	1998
15546855	Surprising versatility of Na+-glucose cotransporters: SLC5 Loo, DD, Hirayama, BA, Turk, E, Wright, EM	Physiology (Bethesda)	2004
16186415	Apical GLUT2: a major pathway of intestinal sugar absorption Kellett, GL, Brot-Laroche, E	Diabetes	2005