Intestinal hexose absorption

Stable Identifier
R-HSA-8981373
Type
Pathway
Species
Homo sapiens
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Hexoses, notably fructose, glucose, and galactose generated in the lumen of the small intestine by breakdown of dietary carbohydrate, are taken up by enterocytes lining the microvilli of the small intestine and released from them into the blood. Uptake into enterocytes is mediated by two transporters localized on the luminal surfaces of the cells. SLC5A1, also known as SGLT1, mediates the co-transport of sodium ions and glucose and galactose, and SLC2A5, also known as GLUT5, mediates fructose uptake (Wright 1998). Tetrameric SLC2A2, also known as GLUT2, localized on the basolateral surfaces of enterocytes, mediates the release of these hexoses into the blood (Kellett & Brot-Laroche 2005; Wright et al. 2004).

Literature References
PubMed ID Title Journal Year
15546855 Surprising versatility of Na+-glucose cotransporters: SLC5

Wright, EM, Loo, DD, Hirayama, BA, Turk, E

Physiology (Bethesda) 2004
9815014 Genetic Disorders of Membrane Transport I. Glucose galactose malabsorption

Wright, EM

Am. J. Physiol. 1998
16186415 Apical GLUT2: a major pathway of intestinal sugar absorption

Kellett, GL, Brot-Laroche, E

Diabetes 2005
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