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Signalling to ERKs
Stable Identifier
R-HSA-187687
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
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Neurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS, ocurring from caveolae in the plasma membrane or from clathrin-coated vesicles, and via RAP1, taking place in early endosomes. Whereas RAS activation by NGF is transient, RAP1 activation by NGF is sustained for hours.
Literature References
PubMed ID
Title
Journal
Year
10508738
Extracellular-signal-regulated kinase signalling in neurons
Stork, PJ
,
Grewal, SS
,
York, RD
Curr Opin Neurobiol
1999
Participants
Events
Signalling to RAS
(Homo sapiens)
Signalling to p38 via RIT and RIN
(Homo sapiens)
Prolonged ERK activation events
(Homo sapiens)
Participates
as an event of
Signaling by NTRK1 (TRKA) (Homo sapiens)
Orthologous Events
Signalling to ERKs (Bos taurus)
Signalling to ERKs (Caenorhabditis elegans)
Signalling to ERKs (Canis familiaris)
Signalling to ERKs (Danio rerio)
Signalling to ERKs (Dictyostelium discoideum)
Signalling to ERKs (Drosophila melanogaster)
Signalling to ERKs (Gallus gallus)
Signalling to ERKs (Mus musculus)
Signalling to ERKs (Plasmodium falciparum)
Signalling to ERKs (Rattus norvegicus)
Signalling to ERKs (Saccharomyces cerevisiae)
Signalling to ERKs (Schizosaccharomyces pombe)
Signalling to ERKs (Sus scrofa)
Signalling to ERKs (Xenopus tropicalis)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
Jassal, B (2006-09-21)
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