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Signalling to p38 via RIT and RIN
Stable Identifier
R-HSA-187706
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to p38 via RIT and RIN (Homo sapiens)
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RIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT and RIN lack a typical prenylation motif (CAAX, XXCC, or CXC) required for the association of RAS proteins with the plasma membrane. RIT is expressed in all tissues, whereas RIN is neuron-specific. They have similar signalling properties and are activated by NGF through unknown exchange factors. They signal to ERKs and p38 MAP kinase. They mainly lead to p38 activation via the BRAF-MEK kinase cascade.
Literature References
PubMed ID
Title
Journal
Year
10712923
The Ras branch of small GTPases: Ras family members don't fall far from the tree
Der, CJ
,
Reuther, GW
Curr Opin Cell Biol
2000
Participants
Events
TRKA recruits RIT and RIN
(Homo sapiens)
RIT/RIN are activated
(Homo sapiens)
RIT/RIN-GTP binds B-RAF
(Homo sapiens)
Participates
as an event of
Signalling to ERKs (Homo sapiens)
Event Information
Go Biological Process
small GTPase-mediated signal transduction (0007264)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
Jassal, B (2006-09-21)
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