Reactome | Signaling by NTRK1 (TRKA)

Signaling by NTRK1 (TRKA)

Stable Identifier

R-HSA-187037

DOI

10.3180/REACT_12056.1

Type

Pathway

Species

Homo sapiens

Synonyms

NGF signalling via TRKA from the plasma membrane

ReviewStatus

5/5

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Trk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes is slower but long lasting. Signalling from the plasma membrane is annotated here. TRK signalling leads to proliferation in some cell types and neuronal differentiation in others. Proliferation is the likely outcome of short term signalling, as observed following stimulation of EGFR (EGF receptor). Long term signalling via TRK receptors, instead, was clearly shown to be required for neuronal differentiation in response to neurotrophins.

Literature References

PubMed ID	Title	Journal	Year
10579918	Neurotrophin signaling via Trks and p75 Greene, LA, Friedman, WJ	Exp Cell Res	1999
12676795	Trk receptors: roles in neuronal signal transduction Reichardt, LF, Huang, EJ	Annu Rev Biochem	2003
11520933	Nerve growth factor signaling, neuroprotection, and neural repair Sofroniew, MV, Howe, CL, Mobley, WC	Annu Rev Neurosci	2001
10851172	Neurotrophin signal transduction in the nervous system Miller, FD, Kaplan, DR	Curr Opin Neurobiol	2000