Reactome | Factor D cleaves C3b-bound Factor B

Factor D cleaves C3b-bound Factor B

Stable Identifier

R-HSA-183122

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Factor D, a constitutively active serine protease found in trace amounts in the blood, cleaves a specific Arg-Lys bond in the Factor B component of the cell surface-associated C3b:Factor B complex, yielding the alternate C3 convertase C3bBb on the surface and releasing an inactive polypeptide, Factor Ba (Lesavre and Muller-Eberhard 1978; Lesavre et al. 1979; Schreiber et al. 1978).

Literature References

PubMed ID	Title	Journal	Year
279011	Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins Schreiber, RD, Pangburn, MK, Lesavre, PH, Muller-Eberhard, HJ	Proc Natl Acad Sci U S A	1978
3052276	Molecular organization and function of the complement system Muller-Eberhard, HJ	Annu Rev Biochem	1988