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Cell surface:C3b:CFB [plasma membrane]
Stable Identifier
R-HSA-173737
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Alternative complement activation (Homo sapiens)
Factor B binds to surface-associated C3b (Homo sapiens)
Cell surface:C3b:CFB [plasma membrane] (Homo sapiens)
Factor D cleaves C3b-bound Factor B (Homo sapiens)
Cell surface:C3b:CFB [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
21205667
Structures of C3b in complex with factors B and D give insight into complement convertase formation
Tzekou, A
,
Ricklin, D
,
Wu, J
,
Gros, P
,
Forneris, F
,
Wallace, RS
,
Lambris, JD
Science
2010
Participants
components
Cell surface:C3b [plasma membrane]
(Homo sapiens)
CFB(26-764) [extracellular region]
(Homo sapiens)
Participates
as an output of
Factor B binds to surface-associated C3b (Homo sapiens)
as an input of
Factor D cleaves C3b-bound Factor B (Homo sapiens)
Inferred To
Cell surface:C3b:CFB [plasma membrane]
(Bos taurus)
Cell surface:C3b:CFB [plasma membrane]
(Canis familiaris)
Cell surface:C3b:CFB [plasma membrane]
(Danio rerio)
Cell surface:C3b:CFB [plasma membrane]
(Gallus gallus)
Cell surface:C3b:CFB [plasma membrane]
(Mus musculus)
Cell surface:C3b:CFB [plasma membrane]
(Sus scrofa)
Cell surface:C3b:CFB [plasma membrane]
(Xenopus tropicalis)
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