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Cell surface:C3b:Bb [plasma membrane]
Stable Identifier
R-HSA-173749
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Surface-associated C3bBb
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Activation of C3 and C5 (Homo sapiens)
Cleavage of C3 by C3 convertases (Homo sapiens)
C3 convertases [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Alternative complement activation (Homo sapiens)
Factor D cleaves C3b-bound Factor B (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
Properdin stabilizes C3b:Bb bound to cell surfaces (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
C3 convertases spontaneously dissociate (Homo sapiens)
C3 convertases [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
CD55 (DAF) binds C3bBb, C4bC2a (Homo sapiens)
C4bC2a, C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
CD55:C3 convertase complexes [plasma membrane] (Homo sapiens)
CD55:C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Homo sapiens)
CD55:C3 convertase complexes [plasma membrane] (Homo sapiens)
CD55:C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
CR1 binds C3bBb/C4bC2a (Homo sapiens)
C4bC2a, C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Homo sapiens)
CR1:C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
Displacement of C2a/Bb by CR1 (Homo sapiens)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Homo sapiens)
CR1:C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
Factor H binds to C3bBb (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
Factor H displaces Bb (Homo sapiens)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15068800
Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase
Macon, K
,
Ponnuraj, K
,
Volanakis, JE
,
Moore, D
,
Xu, Y
,
Narayana, SV
Mol. Cell
2004
Participants
components
C3b [extracellular region]
(Homo sapiens)
Cell surface [plasma membrane]
CFB(260-764) [plasma membrane]
(Homo sapiens)
Participates
as a component of
CD55:C3bBb [plasma membrane] (Homo sapiens)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Homo sapiens)
CR1:C3bBb [plasma membrane] (Homo sapiens)
as an input of
Factor H binds to C3bBb (Homo sapiens)
Properdin stabilizes C3b:Bb bound to cell surfaces (Homo sapiens)
as a member of
C4bC2a, C3bBb [plasma membrane] (Homo sapiens)
C3 convertases [plasma membrane] (Homo sapiens)
as an output of
Factor D cleaves C3b-bound Factor B (Homo sapiens)
Inferred To
Cell surface:C3b:Bb [plasma membrane]
(Bos taurus)
Cell surface:C3b:Bb [plasma membrane]
(Canis familiaris)
Cell surface:C3b:Bb [plasma membrane]
(Danio rerio)
Cell surface:C3b:Bb [plasma membrane]
(Mus musculus)
Cell surface:C3b:Bb [plasma membrane]
(Sus scrofa)
Cell surface:C3b:Bb [plasma membrane]
(Xenopus tropicalis)
Cross References
ComplexPortal
CPX-5601
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