ZBP1(DAI) recruits RIP1 and RIP3

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Human alphaherpesvirus 2, Human cytomegalovirus
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Two RIP homotypic interaction motifs (RHIM) were identified in the DAI protein sequence. These two domains were shown to be essential for DAI-induced NFkB activation in human embryonic kidney 293T (HEK293T) cells. DAI forms a complex with two RHIM-containing kinases - RIP1 and RIP3 (Kaiser WJ et al 2008, Rebsamen M et al 2009). Recruitment of RIP3 to DAI was reported to induce RIP3 autophosphorylation. Furthermore, knockdown of RIP1 or RIP3 affected DAI-induced NFkB signals in murine L929 fibroblast and human HEK293T cells (Kaiser WJ et al 2008, Rebsamen M et al 2009).

Literature References
PubMed ID Title Journal Year
18941233 Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors

Mocarski, ES, Kaiser, WJ, Upton, JW

J Immunol 2008
19590578 DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

Benedict, CA, Rebsamen, M, Vazquez, J, Hofmann, K, Michallet, MC, Schroder, K, Meylan, E, Tschopp, J, Heinz, LX

EMBO Rep 2009
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