ZBP1(DAI) recruits RIP1 and RIP3

Stable Identifier
R-HSA-1810457
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human alphaherpesvirus 2, Human cytomegalovirus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ZBP1(DAI) recruits RIP1 and RIP3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Two RIP homotypic interaction motifs (RHIM) were identified in the DAI protein sequence. These two domains were shown to be essential for DAI-induced NFkB activation in human embryonic kidney 293T (HEK293T) cells. DAI forms a complex with two RHIM-containing kinases - RIP1 and RIP3 (Kaiser WJ et al 2008, Rebsamen M et al 2009). Recruitment of RIP3 to DAI was reported to induce RIP3 autophosphorylation. Furthermore, knockdown of RIP1 or RIP3 affected DAI-induced NFkB signals in murine L929 fibroblast and human HEK293T cells (Kaiser WJ et al 2008, Rebsamen M et al 2009).
Literature References
PubMed ID Title Journal Year
18941233 Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors

Kaiser, WJ, Upton, JW, Mocarski, ES

J Immunol 2008
19590578 DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

Rebsamen, M, Heinz, LX, Meylan, E, Michallet, MC, Schroder, K, Hofmann, K, Vazquez, J, Benedict, CA, Tschopp, J

EMBO Rep 2009
Participants
Input
Output
Participates
as an event of
Authored
Shamovsky, V  (2011-09-21)
Reviewed
D'Eustachio, P  (2011-12-08)
Upton, JW  (2012-02-19)
Mocarski, ES  (2012-02-19)
Created
Shamovsky, V  (2011-10-25)
Cite Us!