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PIP4K2B [cytosol]
Stable Identifier
R-HSA-1806208
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PIP5K2B
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Homo sapiens)
PIP4K2/5K1 [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
PIP4K2 dimers [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2C [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
PIP4K2 dimers [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2C [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78356 PIP4K2B
Gene Names
PIP4K2B, PIP5K2B
Chain
initiator methionine:, chain:2-416
Reference Genes
BioGPS Gene:8396 PIP4K2B
CTD Gene:8396 PIP4K2B
dbSNP Gene:8396 PIP4K2B
ENSEMBL:ENSG00000276293 PIP4K2B
ENSEMBL_homo_sapiens_GENE:ENSG00000276293.5 PIP4K2B
ENSEMBL_homo_sapiens_GENE:ENSG00000277292.2 PIP4K2B
HGNC:8998 PIP4K2B
KEGG Gene (Homo sapiens):8396 PIP4K2B
Monarch:8396 PIP4K2B
NCBI Gene:8396 PIP4K2B
OMIM:603261 PIP4K2B
UCSC:P78356 PIP4K2B
Reference Transcript
RefSeq:NM_003559.4 PIP4K2B
Other Identifiers
11715886_at
11715887_s_at
11715888_s_at
11749982_a_at
1553048_PM_a_at
1553048_a_at
16844000
201080_PM_at
201080_at
201081_PM_s_at
201081_s_at
35741_at
3755360
3755361
3755362
3755363
3755365
3755367
3755368
3755369
3755370
3755374
3755375
3755376
3755377
3755379
3755380
3755384
3755385
3755386
48747_at
8014723
8396
A_23_P362207
A_23_P407115
A_24_P245246
GE59503
GO:0000166
GO:0003824
GO:0005515
GO:0005524
GO:0005525
GO:0005634
GO:0005654
GO:0005737
GO:0005773
GO:0005776
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006629
GO:0006914
GO:0007166
GO:0010506
GO:0016020
GO:0016192
GO:0016301
GO:0016307
GO:0016308
GO:0016309
GO:0016310
GO:0016740
GO:0023052
GO:0042803
GO:0043226
GO:0046488
GO:0046627
GO:0046854
GO:0052742
GO:0061024
GO:0061909
GO:1902635
GO:2000786
HMNXSV003048405
Hs.6335.0.S2_3p_at
Hs2.6335.2.A1_3p_s_at
ILMN_1701213
ILMN_1741017
PH_hs_0023530
TC17001433.hg
U85245_at
g4505818_3p_a_at
Participates
as a component of
PIP4K2A:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2C [cytosol] (Homo sapiens)
Other forms of this molecule
p-S326-PIP4K2B [nucleoplasm]
PIP4K2B [nucleoplasm]
Inferred To
ppk-2 [cytosol]
(Caenorhabditis elegans)
PIP4K [cytosol]
(Drosophila melanogaster)
PIP4K2B [cytosol]
(Bos taurus)
PIP4K2B [cytosol]
(Canis familiaris)
PIP4K2B [cytosol]
(Dictyostelium discoideum)
PIP4K2B [cytosol]
(Gallus gallus)
PIP4K2B [cytosol]
(Mus musculus)
PIP4K2B [cytosol]
(Plasmodium falciparum)
PIP4K2B [cytosol]
(Rattus norvegicus)
PIP4K2B [cytosol]
(Sus scrofa)
pip4k2b [cytosol]
(Xenopus tropicalis)
MSS4 [cytosol]
(Saccharomyces cerevisiae)
its3 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_003550.1
ZINC - World Drugs
PI42B_HUMAN
Guide to Pharmacology - Targets
2162
OpenTargets
ENSG00000276293
ZINC - FDA approved
PI42B_HUMAN
ZINC - Substances
PI42B_HUMAN
ZINC - Biogenic
PI42B_HUMAN
ZINC target
P78356
PRO
P78356
PDB
3X09
,
6K4G
,
3X08
,
6K4H
,
7N81
,
7EM8
,
3WZZ
,
7EM7
,
7N80
,
1BO1
,
3X07
,
3X05
,
3X06
,
7EM6
,
3X0C
,
7EM4
,
7EM5
,
3X03
,
3X0B
,
7EM3
,
3X04
,
3X0A
,
7EM2
,
3X01
,
7EM1
,
3X02
ZINC - Investigational
PI42B_HUMAN
HPA
ENSG00000276293-PIP4K2B
GeneCards
P78356
Ensembl
ENSP00000482548
,
ENSP00000480776
,
ENSG00000277292
,
ENSG00000276293
,
ENST00000613180
,
ENST00000619039
Pharos - Targets
P78356
ZINC - Predictions - Purchasable
PI42B_HUMAN
HMDB Protein
HMDBP01354
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
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