Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PIP4K2B [cytosol]
Stable Identifier
R-HSA-1806208
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PIP5K2B
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Homo sapiens)
PIP4K2/5K1 [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
PIP4K2 dimers [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2C [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
PIP4K2 dimers [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2C [cytosol] (Homo sapiens)
PIP4K2B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78356 PIP4K2B
Gene Names
PIP4K2B, PIP5K2B
Chain
initiator methionine:1, chain:2-416
Reference Genes
BioGPS Gene:8396 PIP4K2B
CTD Gene:8396 PIP4K2B
dbSNP Gene:8396 PIP4K2B
ENSEMBL:ENSG00000276293 PIP4K2B
HGNC:8998 PIP4K2B
KEGG:hsa:8396 PIP4K2B
Monarch:8396 PIP4K2B
NCBI Gene:8396 PIP4K2B
OMIM:603261 PIP4K2B
UCSC:P78356 PIP4K2B
Reference Transcript
RefSeq:NM_003559.5 PIP4K2B
Participates
as a component of
PIP4K2A:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2B:PIP4K2C [cytosol] (Homo sapiens)
Other forms of this molecule
PIP4K2B [nucleoplasm]
p-S326-PIP4K2B [nucleoplasm]
Inferred To
ppk-2 [cytosol]
(Caenorhabditis elegans)
PIP5K [cytosol]
(Plasmodium falciparum)
PIP4K [cytosol]
(Drosophila melanogaster)
PIP4K2B [cytosol]
(Bos taurus)
PIP4K2B [cytosol]
(Canis familiaris)
PIP4K2B [cytosol]
(Dictyostelium discoideum)
PIP4K2B [cytosol]
(Gallus gallus)
PIP4K2B [cytosol]
(Sus scrofa)
Pip4k2b [cytosol]
(Mus musculus)
Pip4k2b [cytosol]
(Rattus norvegicus)
pip4k2b [cytosol]
(Xenopus tropicalis)
MSS4 [cytosol]
(Saccharomyces cerevisiae)
its3 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_003550.1
ZINC - World Drugs
PI42B_HUMAN
Guide to Pharmacology - Targets
2162
OpenTargets
ENSG00000276293
ENSEMBL
ENSG00000277292
,
ENSP00000482548
,
ENSP00000480776
,
ENST00000619039
,
ENSG00000276293
,
ENST00000613180
ZINC - FDA approved
PI42B_HUMAN
ZINC - Substances
PI42B_HUMAN
ZINC - Biogenic
PI42B_HUMAN
ZINC target
P78356
PRO
P78356
GlyGen
P78356
PDB
3X0B
,
3X03
,
7EM6
,
7EM4
,
7EM3
,
7EM5
,
3X05
,
3X04
,
3WZZ
,
3X07
,
3X02
,
3X06
,
3X01
,
3X09
,
3X0C
,
3X08
,
3X0A
,
6K4G
,
6K4H
,
7EM2
,
1BO1
,
7N81
,
7EM1
,
7N80
,
7EM8
,
7EM7
ZINC - Investigational
PI42B_HUMAN
HPA
ENSG00000276293-PIP4K2B
GeneCards
PIP4K2B
Pharos - Targets
P78356
ZINC - Predictions - Purchasable
PI42B_HUMAN
HMDB Protein
HMDBP01354
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UH99 SUN2
1
SUN2 [nuclear envelope]
(R-HSA-912382)
0.527
3
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
0.527
4
UniProt:Q15831 STK11
2
STK11 [cytosol]
(R-HSA-380954)
STK11 [nucleoplasm]
(R-HSA-164119)
0.527
2
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.527
3
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text