Expression of Carnitine O-palmitoyltransferase 1 CPT1A

Stable Identifier
R-HSA-1801587
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial outer membrane
ReviewStatus
5/5
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Expression of Carnitine O-palmitoyltransferase 1 CPT1A
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The CPT1A gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Britton et al. 1995, Johnson et al. 2002, Rakhshanderoo et al. 2009). As inferred from mouse homologs, RORA binds RRE DNA elements in the promoter of CPT1A and recruits the coactivators PGC-1alpha (PPARGC1A) and p300 (EP300, a histone acetylase) to enhance transcription of CPT1A. Regulation by RORA imparts circadian expression on CPT1A (Arnardottir et al. 2014), which encodes Carnitine O-palmitoyltransferase 1, an enzyme required for uptake and beta oxidation of fatty acids by mitochondria. Ppara, Rxra, and Per2 regulate the transcription of CPT1A (Chavan et al. 2016), which is important for food anticipatory activity in mice.
Literature References
PubMed ID Title Journal Year
19710929 Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human

Rakhshandehroo, M, Hooiveld, G, Muller, M, Kersten, S

PLoS One 2009
7892212 Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the gene

Britton, CH, Schultz, RA, Zhang, B, Esser, V, Foster, DW, McGarry, JD

Proc Natl Acad Sci U S A 1995
12505311 Regulation of P450 4A expression by peroxisome proliferator activated receptors

Johnson, EF, Hsu, MH, Savas, U, Griffin, KJ

Toxicology 2002
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
positive regulation of transcription by RNA polymerase II (0045944)
This event is regulated
Positively by
Regulator
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Regulator
RORA:EP300:CPT1A gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Cpt1a (Mus musculus)
Authored
May, B  (2011-10-23)
Reviewed
Kersten, S  (2009-06-08)
Delaunay, F  (2012-01-28)
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2011-10-24)
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