Expression of CPT1A

Stable Identifier
R-HSA-1801587
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The CPT1A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

Literature References
PubMed ID Title Journal Year
7892212 Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the gene

Britton, CH, Schultz, RA, Zhang, B, Esser, V, Foster, DW, McGarry, JD

Proc Natl Acad Sci U S A 1995
19710929 Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human

Rakhshandehroo, M, Hooiveld, G, Muller, M, Kersten, S

PLoS One 2009
12505311 Regulation of P450 4A expression by peroxisome proliferator activated receptors

Johnson, EF, Hsu, MH, Savas, U, Griffin, KJ

Toxicology 2002
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Regulator
Summation

As inferred from mouse, RORA binds RRE DNA elements and recruits the coactivators PGC-1alpha (PPARGC1A) and p300 (EP300, a histone acetylase). As inferred from mouse, ROR-alpha binds the promoter of the CPT1A gene and, together with coactivators EP300 and PGC-1alpha, enhances transcription.

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