PPARA activates gene expression

Stable Identifier
R-HSA-1989781
Type
Pathway
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane, extracellular region, lipid droplet, mitochondrial inner membrane, mitochondrial matrix, mitochondrial outer membrane, nucleoplasm, peroxisomal matrix, peroxisomal membrane, plasma membrane
ReviewStatus
5/5
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PPARA activates gene expression
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The set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor elements (PPREs) in their promoters and include:
1) genes involved in fatty acid oxidation and ketogenesis (Acox1, Cyp4a, Acadm, Hmgcs2);
2) genes involved in fatty acid transport (Cd36, , Slc27a1, Fabp1, Cpt1a, Cpt2);
3) genes involved in producing fatty acids and very low density lipoproteins (Me1, Scd1);
4) genes encoding apolipoproteins (Apoa1, Apoa2, Apoa5);
5) genes involved in triglyceride clearance ( Angptl4);
6) genes involved in glycerol metabolism (Gpd1 in mouse);
7) genes involved in glucose metabolism (Pdk4);
8) genes involved in peroxisome proliferation (Pex11a);
9) genes involved in lipid storage (Plin, Adfp).
Many other genes are known to be regulated by PPAR-alpha but whether their regulation is direct or indirect remains to be found. These genes include: ACACA, FAS, SREBP1, FADS1, DGAT1, ABCA1, PLTP, ABCB4, UGT2B4, SULT2A1, Pnpla2, Acsl1, Slc27a4, many Acot genes, and others (reviewed in Rakhshandehroo et al. 2010).
Literature References
PubMed ID Title Journal Year
14999402 Peroxisome proliferator-activated receptor alpha target genes

Mandard, S, Kersten, S, Muller, M

Cell Mol Life Sci 2004
10529898 Peroxisome proliferator-activated receptors: nuclear control of metabolism

Wahli, W, Desvergne, B

Endocr Rev 1999
20936127 Peroxisome proliferator-activated receptor alpha target genes

Kersten, S, Knoch, B, Rakhshandehroo, M, Müller, M

PPAR Res 2010
11330046 Peroxisome proliferator-activated receptors, coactivators, and downstream targets

Qi, C, Reddy, JK, Zhu, Y

Cell Biochem Biophys 2000
18288277 Peroxisome proliferator activated receptors and lipoprotein metabolism

Kersten, S

PPAR Res 2008
Participants
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Event Information
Go Biological Process
regulation of metabolic process (0019222)
Authored
May, B  (2011-11-08)
Reviewed
Kersten, S  (2009-06-08)
Created
May, B  (2011-11-13)
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