Expression of Cpt1a

Stable Identifier
R-MMU-1368145
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, mitochondrial outer membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Cpt1a
The Cpt1a gene is transcribed to yield mRNA (Mootha et al. 2003, Uenaka et al. 1996) and the mRNA is translated to yield protein. Rora together with coactivators enhances transcription of Cpt1a (Lau et al. 2004).
Literature References
PubMed ID Title Journal Year
8830050 Increased expression of carnitine palmitoyltransferase I gene is repressed by administering L-carnitine in the hearts of carnitine-deficient juvenile visceral steatosis mice

Uenaka, R, Kuwajima, M, Ono, A, Matsuzawa, Y, Hayakawa, J, Inohara, N, Kagawa, Y, Ohta, S

J Biochem 1996
15199055 RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR

Lau, P, Nixon, SJ, Parton, RG, Muscat, GE

J Biol Chem 2004
14651853 Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

Mootha, VK, Bunkenborg, J, Olsen, JV, Hjerrild, M, Wisniewski, JR, Stahl, E, Bolouri, MS, Ray, HN, Sihag, S, Kamal, M, Patterson, N, Lander, ES, Mann, M

Cell 2003
Participants
Input
Output
This event is regulated
Positively by
Regulator
Rora:Ep300:Cpt1a gene [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of Carnitine O-palmitoyltransferase 1 CPT1A (Homo sapiens)
Authored
May, B  (2011-06-22)
Reviewed
Delaunay, F  (2012-01-28)
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2011-06-30)
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