RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression

Stable Identifier
R-HSA-9933387
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
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Both Retinoid-related orphan receptors (RORA, RORB, RORC) and the heme-binding nuclear receptor NR1D1 (REV-ERBA) bind ROR response elements (RREs, ROREs) in DNA (reviewed in Duez and Staels 2008, Cox and Takahashi 2019, Laothamatas et al. 2023). RORs and NR1D1 produce opposite effects, however: RORs recruit coactivators such as EP300 (p300) and PPARGC1A to activate transcription; NR1D1 recruits the corepressor NCOR1 and the histone deacetylase HDAC3 to repress transcription.
Literature References
PubMed ID Title Journal Year
31557726 Circadian clock genes and the transcriptional architecture of the clock mechanism

Cox, KH, Takahashi, JS

J Mol Endocrinol 2019
37708890 Metabolic and chemical architecture of the mammalian circadian clock

Laothamatas, I, Rasmussen, ES, Green, CB, Takahashi, JS

Cell Chem Biol 2023
18537094 The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism

Duez, H, Staels, B

Diab Vasc Dis Res 2008
Participants
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Authored
May, B  (2024-12-28)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-12-29)
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