IDS hydrolyses dermatan sulfate (Chebi:63517 chain)

Stable Identifier
R-HSA-1793182
Type
Reaction
Species
Homo sapiens
Compartment
lysosomal lumen
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IDS hydrolyses dermatan sulfate (Chebi:63517 chain)
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Iduronate 2-sulfatase (IDS) hydrolyses 2-sulfate groups from L-iduronate 2-sulfate units of dermatan sulfate in the lysosome. Defects in IDS are the cause of mucopolysaccharidosis type II (MPSII, MIM:309900), also called Hunter syndrome (Wilson et al. 1990).

Literature References
PubMed ID Title Journal Year
2122463 Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA

Morris, CP, Bielicki, J, Occhiodoro, T, Hopwood, JJ, Anson, DS, Clements, PR, Wilson, PJ

Proc Natl Acad Sci U S A 1990
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Output
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Catalyst Activity

iduronate-2-sulfatase activity of IDS dimer [lysosomal lumen]

Physical Entity
IDS dimer [lysosomal lumen] (Homo sapiens)
Activity
iduronate-2-sulfatase activity (GO:0004423)
Orthologous Events
IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Bos taurus)
IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Canis familiaris)
IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Danio rerio)
IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Drosophila melanogaster)
IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Gallus gallus)
IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Mus musculus)
IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Rattus norvegicus)
IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Sus scrofa)
IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Xenopus tropicalis)
Authored
Jassal, B  (2011-10-21)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-10-21)
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