CS/DS degradation

Stable Identifier
R-HSA-2024101
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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CS/DS degradation
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Lysosomal degradation of glycoproteins is part of the cellular homeostasis of glycosylation (Winchester 2005). The steps outlined below describe the degradation of chondroitin sulfate and dermatan sulfate. Complete degradation of glycoproteins is required to avoid build up of glycosaminoglycan fragments which can cause lysosomal storage diseases. Complete degradation steps are not shown as they are repetitions of the main ones described here. The proteolysis of the core protein of the glycoprotein is not shown here.
Literature References
PubMed ID Title Journal Year
15647514 Lysosomal metabolism of glycoproteins

Winchester, B

Glycobiology 2005
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
glycosaminoglycan catabolic process (0006027)
Orthologous Events
CS/DS degradation (Bos taurus)
CS/DS degradation (Caenorhabditis elegans)
CS/DS degradation (Canis familiaris)
CS/DS degradation (Danio rerio)
CS/DS degradation (Dictyostelium discoideum)
CS/DS degradation (Drosophila melanogaster)
CS/DS degradation (Gallus gallus)
CS/DS degradation (Mus musculus)
CS/DS degradation (Rattus norvegicus)
CS/DS degradation (Sus scrofa)
CS/DS degradation (Xenopus tropicalis)
Authored
Jassal, B  (2011-12-14)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-12-14)
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