Reactome | Expression of DDIT3

Expression of DDIT3

Stable Identifier

R-CGR-9635841

Type

Reaction [omitted]

Species

Cricetulus griseus

Compartment

nucleoplasm

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

The DDIT3 (CHOP) gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Fornace et al. 1988, Wang et al. 1996, Ma et al. 2002). Expression of DDIT3 is activated by DNA damage (Fornace et al. 1988) and by NF-Y and ATF4 in response to endoplasmic reticulum stress (Wang et al. 1996, Ma et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
8754828	Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153) Mi, LJ, Kreibich, G, Lawson, B, Boorstein, R, Ron, D, Wang, XZ, Hendershot, LM, Sanjay, A, Zinszner, H, Brewer, JW	Mol. Cell. Biol.	1996
12083523	Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response Brewer, JW, Ma, Y, Hendershot, LM, Diehl, JA	J Mol Biol	2002
3194391	DNA damage-inducible transcripts in mammalian cells Alamo, I, Fornace, AJ, Hollander, MC	Proc. Natl. Acad. Sci. U.S.A.	1988