Expression of DDIT3

Stable Identifier
R-CGR-9635841
Type
Reaction [omitted]
Species
Cricetulus griseus
Compartment
General
SVG |   | PPTX  | SBGN
Expression of DDIT3

The DDIT3 (CHOP) gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Fornace et al. 1988, Wang et al. 1996, Ma et al. 2002). Expression of DDIT3 is activated by DNA damage (Fornace et al. 1988) and by NF-Y and ATF4 in response to endoplasmic reticulum stress (Wang et al. 1996, Ma et al. 2002).

Literature References
PubMed ID Title Journal Year
12083523 Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

Ma, Y, Brewer, JW, Diehl, JA, Hendershot, LM

J Mol Biol 2002
8754828 Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153)

Wang, XZ, Lawson, B, Brewer, JW, Zinszner, H, Sanjay, A, Mi, LJ, Boorstein, R, Kreibich, G, Hendershot, LM, Ron, D

Mol. Cell. Biol. 1996
3194391 DNA damage-inducible transcripts in mammalian cells

Fornace, AJ, Alamo, I, Hollander, MC

Proc. Natl. Acad. Sci. U.S.A. 1988
Participants
This event is regulated
Orthologous Events
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