Reactome | ATF6 (ATF6-alpha) activates chaperone genes

ATF6 (ATF6-alpha) activates chaperone genes

Stable Identifier

R-HSA-381183

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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ATF6 (ATF6-alpha) activates chaperone genes

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The N-terminal fragment of ATF6-alpha contains a bZIP domain and binds the sequence CCACG in ER Stress Response Elements (ERSEs). ATF6-alpha binds ERSEs together with the heterotrimeric transcription factor NF-Y, which binds the sequence CCAAT in the ERSEs, and together the two factors activate transcription of ER stress-responsive genes. Evidence from overexpression and knockdowns indicates that ATF6-alpha is a potent activator but its homolog ATF6-beta is not and ATF6-beta may actually reduce expression of ER stress proteins.

Literature References

PubMed ID	Title	Journal	Year
14973138	Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction Thuerauf, DJ, Morrison, L, Glembotski, CC	J Biol Chem	2004
12014989	Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response Okada, T, Yoshida, H, Akazawa, R, Negishi, M, Mori, K	Biochem. J.	2002
10958673	ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response Yoshida, H, Okada, T, Haze, K, Yanagi, H, Yura, T, Negishi, M, Mori, K	Mol Cell Biol	2000
10866666	ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1 Li, M, Baumeister, P, Roy, B, Phan, T, Foti, D, Luo, S, Lee, AS	Mol Cell Biol	2000
25821458	Transcriptional regulation of secretory capacity by bZip transcription factors Fox, RM, Andrew, DJ	Front Biol (Beijing)	2015
10856300	Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response Wang, Y, Shen, J, Arenzana, N, Tirasophon, W, Kaufman, RJ, Prywes, R	J Biol Chem	2000

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ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)

Event Information

Go Biological Process

ATF6-mediated unfolded protein response (0036500)

Authored

May, B (2009-06-02)

Reviewed

D'Eustachio, P (2008-12-02)

Matthews, L (2008-12-02)

Gillespie, ME (2008-12-02)

Urano, F (2010-04-30)

Created

May, B (2008-11-19)

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