ATR:ATRIP

Stable Identifier
R-HSA-176269
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
ATR-ATRIP, ATM- and rad3-related (ATR), ATR-interacting protein (ATRIP)
Locations in the PathwayBrowser
Summation

The ATR (ATM- and rad3-related) kinase is an essential checkpoint factor in human cells. In response to replication stress (i.e., stresses that cause replication fork stalling) or ultraviolet radiation, ATR becomes active and phosphorylates numerous factors involved in the checkpoint response including the checkpoint kinase Chk1. ATR is invariably associated with ATRIP (ATR-interacting protein) in human cells. Depletion of ATRIP by siRNA causes a loss of ATR without affecting ATR mRNA levels indicating that complex formation stabilizes ATR. ATRIP is also a substrate for the ATR kinase, but this modification does not play a significant role in the recruitment of ATR-ATRIP to sites of damage, the activation of Chk1, or the modification of p53.

Literature References
PubMed ID Title Journal Year
16027118 ATRIP oligomerization is required for ATR-dependent checkpoint signaling

Ball, HL, Cortez, D

J Biol Chem 2005
14729973 Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities

Unsal-Kacmaz, K, Sancar, A

Mol Cell Biol 2004
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