Reactome | The complex of ATR and ATRIP is recruited to ICL-DNA

The complex of ATR and ATRIP is recruited to ICL-DNA

Stable Identifier

R-HSA-6788385

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The complex of ATR and ATRIP is recruited to ICL-DNA

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The complex of ATR and ATRIP (ATR:ATRIP) is recruited to replication forks blocked by DNA interstrand crosslinks (ICL-DNA) through interaction with the RPA complex and the Fanconi anemia (FA) core complex. The RPA heterotrimer associates both with single strand DNA (ssDNA) that is produced by DNA resection at ICL-DNA-stalled replication forks and with the FANCM and FAAP24 components of the FA core complex (Huang et al. 2010). ATRIP directly interacts with the FANCL component of the FA core complex (Tomida et al. 2013). The presence of RAD17 and TOPB1, which is required for ATR activation at DNA double strand breaks (DSBs), is not needed for ATR activation at ICL-DNA (Tomida et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
20670894	The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response Zou, L, Shiotani, B, Yang, K, D'Andrea, AD, Kim, JM, Huang, M	Mol. Cell	2010
23723247	A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair Kobayashi, M, Masuda, Y, Ishiai, M, Matsuura, A, Matsuda, T, Maehara, Y, Ikura, M, Kamiya, K, Yamamoto, K, Adachi, J, Unno, J, Takata, M, Ikura, T, Meetei, AR, Uchida, E, Shigechi, T, Matsuda, S, Tomida, J, Itaya, A	Nucleic Acids Res.	2013