An unknown DNA ligase ligates single strand breaks (SSBs) remaining after RAD52-mediated single strand annealing (SSA) of resected DNA double-strand breaks (DSBs) and cleavage of displaced flaps by ERCC1:XPF (ERCC1:ERCC4). The product of SSA is a double-strand DNA with a deletion of one complementary region (repeat) and the sequence lying between the two complementary regions used for SSA (inter-SSA deletion) (reviewed by Ciccia and Elledge 2010).
Elledge, SJ, Ciccia, A
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