Completion of SSA

Stable Identifier
R-HSA-5686663
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
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Completion of SSA
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An unknown DNA ligase ligates single strand breaks (SSBs) remaining after RAD52-mediated single strand annealing (SSA) of resected DNA double strand breaks (DSBs) and cleavage of displaced flaps by ERCC1:XPF (ERCC1:ERCC4). The product of SSA is a double-strand DNA with a deletion of one complementary region (repeat) and the sequence lying between the two complementary regions used for SSA (inter-SSA deletion) (reviewed by Ciccia and Elledge 2010).

Literature References
PubMed ID Title Journal Year
20965415 The DNA damage response: making it safe to play with knives

Ciccia, A, Elledge, SJ

Mol. Cell 2010
Participants
Input
Output
Participant Of
hasEvent
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-04-02)