Binding of ATR:ATRIP to RPA at resected DNA DSBs

Stable Identifier
R-HSA-5684875
Type
Reaction [binding]
Species
Homo sapiens
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ATR (ATM- and rad3-related) kinase is an essential checkpoint factor in human cells constitutively associated with ATRIP (ATR-interacting protein). The ATR:ATRIP complex binds RPA complex (RPA1:RPA2:RPA3) associated with ssDNA at resected DNA double strand breaks (DSBs). Complex formation is primarily mediated by physical interaction between ATRIP and RPA1 (Zou and Elledge 2003, Jazayeri et al. 2006).

Literature References
PubMed ID Title Journal Year
12791985 Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

Zou, L, Elledge, SJ

Science 2003
16327781 ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Jazayeri, A, Falck, J, Lukas, C, Bartek, J, Smith, GC, Lukas, J, Jackson, SP

Nat Cell Biol 2006
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Orthologous Events
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