Reactome | Binding of ATR:ATRIP to RPA at resected DNA DSBs

Binding of ATR:ATRIP to RPA at resected DNA DSBs

Stable Identifier

R-HSA-5684875

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Binding of ATR:ATRIP to RPA at resected DNA DSBs

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ATR (ATM- and rad3-related) kinase is an essential checkpoint factor in human cells constitutively associated with ATRIP (ATR-interacting protein). The ATR:ATRIP complex binds RPA complex (RPA1:RPA2:RPA3) associated with ssDNA at resected DNA double-strand breaks (DSBs). Complex formation is primarily mediated by physical interaction between ATRIP and RPA1 (Zou and Elledge 2003, Jazayeri et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16327781	ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks Jazayeri, A, Falck, J, Lukas, C, Jackson, SP, Smith, GC, Lukas, J, Bartek, J	Nat Cell Biol	2006
12791985	Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes Zou, L, Elledge, SJ	Science	2003