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Synthesis And Processing Of GAG, GAGPOL Polyproteins
Stable Identifier
R-HSA-174495
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Synonyms
Synthesis and organization of GAG, GAGPOL polyproteins
ReviewStatus
5/5
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Late Phase of HIV Life Cycle (Homo sapiens)
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Synthesis And Processing Of GAG, GAGPOL Polyproteins (Homo sapiens)
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Evidence suggests that the RNA molecules used for the synthesis of Gag and Gag-Pro-Pol are not the same molecules that are packaged into virions. Gag proteins do not appear to aggregate around and capture the RNA contained in the polyribosome from which they emerged, but rather bind to and ultimately encapsidate free transcripts elsewhere. During the replication of retroviruses, large numbers of Gag molecules must be generated to serve as precursors to the structural proteins of the virions. Retroviruses have developed a mechanism that permits expression of the Gag protein at high levels relative to the protein sequences encoded in the pro and pol genes, while retaining coregulated expression. This linkage results from the use of the same initiation codon in the same mRNA to express the gag, pro, and pol genes. Translation of this RNA leads occasionally to synthesis of a fusion protein that is usually called the Gag-Pol precursor but is now more appropriately called the Gag-Pro-Pol precursor
Literature References
PubMed ID
Title
Journal
Year
Retroviruses
Varmus, HE
,
Hughes, SH
,
Coffin, JM
1997
Participants
Events
Synthesis of GAG polyprotein
(Homo sapiens)
Membrane binding and targetting of GAG proteins
(Homo sapiens)
Participates
as an event of
Assembly Of The HIV Virion (Homo sapiens)
Event Information
Go Biological Process
viral protein processing (0019082)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Cross References
BioModels Database
BIOMD0000000293
,
BIOMD0000000220
Authored
Gillespie, ME (2013-03-07)
Reviewed
Dube, M (2013-05-21)
Created
Gopinathrao, G (2006-02-18)
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