Reactome | Degradation of multiubiquitinated Securin

Degradation of multiubiquitinated Securin

Stable Identifier

R-HSA-174202

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        Degradation of multiubiquitinated Securin (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
        
        Degradation of multiubiquitinated Securin (Homo sapiens)

General

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SVG | | PPTX | SBGN

Degradation of multiubiquitinated Securin

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Following ubiquitination, securin is degraded by the 26S proteasome.

Literature References

PubMed ID	Title	Journal	Year
12070128	Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1 Hagting, A, Den Elzen, N, Vodermaier, HC, Waizenegger, IC, Peters, JM, Pines, J	J Cell Biol	2002