UDP-glucose is oxidised to UDP-glucuronate

Stable Identifier
R-HSA-173597
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid. The cytosolic enzyme is active as a hexamer and performs two successive oxidations to convert the 6'-hydroxyl of UDP-glucose to a carboxylate with concurrent reduction of 2 mol of NAD+ to NADH.

Literature References
PubMed ID Title Journal Year
15044486 Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations

Sommer, BJ, Barycki, JJ, Simpson, MA

J Biol Chem 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
UDP-glucose 6-dehydrogenase activity of 6xUGDH [cytosol]
Physical Entity
Activity
Orthologous Events
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