UDP-glucose is oxidised to UDP-glucuronate

Stable Identifier
R-HSA-173597
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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UDP-glucose is oxidised to UDP-glucuronate
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UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid. The cytosolic enzyme is active as a hexamer and performs two successive oxidations to convert the 6'-hydroxyl of UDP-glucose to a carboxylate with concurrent reduction of 2 mol of NAD+ to NADH.

Literature References
PubMed ID Title Journal Year
15044486 Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations

Barycki, JJ, Simpson, MA, Sommer, BJ

J Biol Chem 2004
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Catalyst Activity

UDP-glucose 6-dehydrogenase activity of 6xUGDH [cytosol]

Physical Entity
6xUGDH [cytosol] (Homo sapiens)
Activity
UDP-glucose 6-dehydrogenase activity (GO:0003979)
Orthologous Events
UDP-glucose is oxidised to UDP-glucuronate (Bos taurus)
UDP-glucose is oxidised to UDP-glucuronate (Caenorhabditis elegans)
UDP-glucose is oxidised to UDP-glucuronate (Canis familiaris)
UDP-glucose is oxidised to UDP-glucuronate (Danio rerio)
UDP-glucose is oxidised to UDP-glucuronate (Drosophila melanogaster)
UDP-glucose is oxidised to UDP-glucuronate (Gallus gallus)
UDP-glucose is oxidised to UDP-glucuronate (Mus musculus)
UDP-glucose is oxidised to UDP-glucuronate (Rattus norvegicus)
UDP-glucose is oxidised to UDP-glucuronate (Sus scrofa)
UDP-glucose is oxidised to UDP-glucuronate (Xenopus tropicalis)
Authored
Jassal, B  (2006-02-14)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2006-02-14)
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