UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid. The cytosolic enzyme is active as a hexamer and performs two successive oxidations to convert the 6'-hydroxyl of UDP-glucose to a carboxylate with concurrent reduction of 2 mol of NAD+ to NADH.
Barycki, JJ, Simpson, MA, Sommer, BJ
UDP-glucose 6-dehydrogenase activity of 6xUGDH [cytosol]
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