Reactome | UDP-glucose is oxidised to UDP-glucuronate

UDP-glucose is oxidised to UDP-glucuronate

Stable Identifier

R-HSA-173597

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

H2O + 2 NAD(+) + UDP-alpha-D-glucose => 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate

ReviewStatus

5/5

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UDP-glucose is oxidised to UDP-glucuronate

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UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid. The cytosolic enzyme is active as a hexamer and performs two successive oxidations to convert the 6'-hydroxyl of UDP-glucose to a carboxylate with concurrent reduction of 2 mol of NAD+ to NADH.

Literature References

PubMed ID	Title	Journal	Year
15044486	Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations Sommer, BJ, Barycki, JJ, Simpson, MA	J Biol Chem	2004