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TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]
Stable Identifier
R-HSA-173476
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TGFB1:TGFBR2:p-5S-T185-TGFBR1:I-SMAD7, TGF-beta 1:type II receptor:Phospho-type I receptor:I-SMAD7 complex
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
Degradation of TGF-beta receptor complex (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
PP1 dephosphorylates TGFBR1 (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
Participants
components
SMAD7 [cytosol]
(Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane]
(Homo sapiens)
Participates
as a component of
TGFB1:TGFBR2:p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
as an output of
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Homo sapiens)
as an input of
SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)
Inferred To
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]
(Bos taurus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]
(Caenorhabditis elegans)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]
(Canis familiaris)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]
(Danio rerio)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]
(Drosophila melanogaster)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]
(Gallus gallus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]
(Mus musculus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]
(Rattus norvegicus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]
(Sus scrofa)
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