Reactome | SMAD7 [cytosol]

SMAD7 [cytosol]

Stable Identifier

R-HSA-173478

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

I-SMAD 7

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - UCH proteinases (Homo sapiens)
      - UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
        
        TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
        
        TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
        
        TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
        
        SMAD7 [cytosol] (Homo sapiens)
        
        TGFB1:TGFBR2:p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
        
        TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
        
        SMAD7 [cytosol] (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
        
        USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Homo sapiens)
        
        SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Homo sapiens)
        
        SMAD7:SMURF2:TGFBR1 [plasma membrane] (Homo sapiens)
        
        SMAD7:SMURF2 [cytosol] (Homo sapiens)
        
        SMAD7 [cytosol] (Homo sapiens)
        
        USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
        
        Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
        
        SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Homo sapiens)
        
        SMAD7 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15105 SMAD7

Gene Names

SMAD7, MADH7, MADH8

Chain

chain:1-426

Reference Genes

BioGPS Gene:4092 SMAD7

COSMIC (genes):SMAD7 SMAD7

CTD Gene:4092 SMAD7

dbSNP Gene:4092 SMAD7

ENSEMBL:ENSG00000101665 SMAD7

ENSEMBL_homo_sapiens_GENE:ENSG00000101665.10 SMAD7

HGNC:6773 SMAD7

KEGG Gene (Homo sapiens):4092 SMAD7

Monarch:4092 SMAD7

NCBI Gene:4092 SMAD7

OMIM:602932 SMAD7

UCSC:O15105 SMAD7

Reference Transcript

Other Identifiers

11725513_a_at

11725514_a_at

11748986_a_at

16855127

1857_at

204790_PM_at

204790_at

3807281

3807282

3807283

3807284

3807292

3807297

3807300

3807302

3807303

3807304

3807305

3807306

3807307

3807308

4092

8023220

AF010193_at

A_23_P55518

GE79885

GO:0000122

GO:0000785

GO:0001650

GO:0001657

GO:0002376

GO:0002725

GO:0003012

GO:0003013

GO:0003714

GO:0005515

GO:0005518

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005912

GO:0006351

GO:0006355

GO:0006357

GO:0007155

GO:0007179

GO:0008013

GO:0009653

GO:0010717

GO:0010719

GO:0010801

GO:0010944

GO:0017015

GO:0022409

GO:0023052

GO:0030154

GO:0030163

GO:0030279

GO:0030336

GO:0030512

GO:0030514

GO:0031397

GO:0031503

GO:0031625

GO:0032436

GO:0032926

GO:0032991

GO:0033137

GO:0034330

GO:0034333

GO:0034616

GO:0034713

GO:0036211

GO:0043226

GO:0046872

GO:0048844

GO:0048856

GO:0048870

GO:0050821

GO:0051444

GO:0055010

GO:0055117

GO:0060090

GO:0060373

GO:0060392

GO:0060395

GO:0060412

GO:0070411

GO:0070697

GO:0071144

GO:0071560

GO:0098772

GO:0140110

GO:0140416

GO:1902731

GO:1903043

GO:1990756

GO:1990830

GO:2000317

GO:2000320

HMNXSV003007961

ILMN_2203891

ILMN_2203896

PH_hs_0032922

TC18000500.hg

g5174516_3p_at

Participates

as a component of

as a member of

I-SMAD [cytosol] (Homo sapiens)

as an input of

as an output of

PP1 dephosphorylates TGFBR1 (Homo sapiens)

Other forms of this molecule

SMAD7 [nucleoplasm]

Inferred To

tag-68 [cytosol] (Caenorhabditis elegans)

Smad7 [cytosol] (Mus musculus)

smad7 [cytosol] (Danio rerio)

Dad [cytosol] (Drosophila melanogaster)

SMAD7 [cytosol] (Bos taurus)

SMAD7 [cytosol] (Canis familiaris)

SMAD7 [cytosol] (Gallus gallus)

SMAD7 [cytosol] (Rattus norvegicus)

SMAD7 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001177751.1, NP_005895.1, NP_001177752.1, NP_001177750.1

OpenTargets

ENSG00000101665

GeneCards

O15105

HPA

ENSG00000101665-SMAD7

Ensembl

ENST00000591805, ENSP00000262158, ENSG00000101665, ENSP00000467621, ENST00000262158, ENSP00000466902, ENST00000589634

PRO

O15105

Pharos - Targets

O15105

HMDB Protein

HMDBP14499

PDB

2LTV, 2KXQ, 2LTX, 2LTY, 2LTW, 2DJY, 2LTZ

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HAU4 SMURF2	2	SMURF2 [nucleoplasm] (R-HSA-178202) SMURF2 [cytosol] (R-HSA-173537)	0.801	7
UniProt:Q9HCE7-1 SMURF1			0.719	4
UniProt:P46937 YAP1	8	p-Y407-YAP1 [cytosol] (R-HSA-9865208) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.715	7
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.639	10
UniProt:Q96PU5-5 NEDD4L			0.611	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.591	5
UniProt:P62942 FKBP1A	1	FKBP1A [cytosol] (R-HSA-2026007)	0.581	3
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) AXIN1 [cytosol] (R-HSA-195249)	0.556	8
UniProt:P36896 ACVR1B	2	ACVR1B [plasma membrane] (R-HSA-205867) p-4S,T188,T206-ACVR1B [plasma membrane] (R-HSA-205780)	0.524	3