SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR

Stable Identifier
R-HSA-178189
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, early endosome membrane, extracellular region, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SMAD7 recruits protein phosphatase 1 (PP1) to TGF-beta receptor complex by binding to the PP1 regulatory subunit PPP1R15A (GADD34). ZFYVE9 (SARA) stabilizes the complex by directly interacting with PP1 catalytic subunit, and presumably TGF-beta receptor complex (Shi et al. 2004). This was deduced based on experiments involving recombinant mouse Smad7 and recombinant human PPP1R15A, TGFBR1, TGFBR2 and SARA.

Literature References
PubMed ID Title Journal Year
14718519 GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

Shi, W, Sun, C, He, B, Xiong, W, Shi, X, Yao, D, Cao, X

J Cell Biol 2004
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Smad7 recruits GADD34:PP1CC to phosphorylated TGF-beta receptor complex (Homo sapiens)
Authored
Heldin, CH  (2006-02-02)
Moustakas, A  (2006-02-02)
Huminiecki, L  (2006-02-02)
Jassal, B  (2006-02-02)
Reviewed
Huang, T  (2012-05-14)
Created
Jassal, B  (2006-04-18)