Adenylate cyclase inhibitory pathway

Stable Identifier
R-HSA-170670
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Adenylate cyclase inhibitory pathway
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Guanine nucleotide-binding protein G(i) alpha (Gi-alpha) inhibits adenylate cyclase, thus inhibiting the production of cAMP from ATP and ultimately decreasing the activity of cAMP-dependent protein kinase.
Literature References
PubMed ID Title Journal Year
8327893 Inhibition of adenylyl cyclase by Gi alpha

Iñiguez-Lluhi, JA, Gilman, AG, Taussig, R

Science 1993
14993377 Isoforms of mammalian adenylyl cyclase: multiplicities of signaling

Sunahara, RK, Taussig, R

Mol Interv 2002
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Events
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Event Information
Go Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (0007193)
Orthologous Events
Adenylate cyclase inhibitory pathway (Bos taurus)
Adenylate cyclase inhibitory pathway (Caenorhabditis elegans)
Adenylate cyclase inhibitory pathway (Canis familiaris)
Adenylate cyclase inhibitory pathway (Danio rerio)
Adenylate cyclase inhibitory pathway (Dictyostelium discoideum)
Adenylate cyclase inhibitory pathway (Drosophila melanogaster)
Adenylate cyclase inhibitory pathway (Gallus gallus)
Adenylate cyclase inhibitory pathway (Mus musculus)
Adenylate cyclase inhibitory pathway (Rattus norvegicus)
Adenylate cyclase inhibitory pathway (Sus scrofa)
Adenylate cyclase inhibitory pathway (Xenopus tropicalis)
Authored
Jassal, B  (2004-03-31)
Le Novere, N  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Jassal, B  (2006-01-10)
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