Reactome | Adenylate cyclase inhibitory pathway

Adenylate cyclase inhibitory pathway

Stable Identifier

R-HSA-170670

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane, cytosol

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)

General

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Guanine nucleotide-binding protein G(i) alpha (Gi-alpha) inhibits adenylate cyclase, thus inhibiting the production of cAMP from ATP and ultimately decreasing the activity of cAMP-dependent protein kinase.

Literature References

PubMed ID	Title	Journal	Year
14993377	Isoforms of mammalian adenylyl cyclase: multiplicities of signaling Sunahara, RK, Taussig, R	Mol Interv	2002
8327893	Inhibition of adenylyl cyclase by Gi alpha Taussig, R, Iñiguez-Lluhi, JA, Gilman, AG	Science	1993