TRIF:activated TLR3/TLR4 complex recruits RIP1

Stable Identifier
R-HSA-168921
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, endosome membrane
ReviewStatus
5/5
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TRIF:activated TLR3/TLR4 complex recruits RIP1
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RIP1 is recruited to the activated TLR receptor by binding to TICAM1(TRIF) via its RHIM motif, followed by its polyubiquitination. Polyubiquitination is possibly mediated by TRAF6 that is also recruited to TICAM1 (Cusson-Hermance N et al. 2005). Other E3-ubiquitin ligases - cIAP1 and cIAP2 - have been reported to promote polyubiquitination of RIP proteins (Bertrand MJM et al. 2011).

RIP3 was shown to inhibit TRIF-induced NFkB activation in dose-dependent manner when overexpressed in HEK293T cells by competing with TRIF to bind RIP1 (Meylan E et al. 2004).

Literature References
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
RIPK3 [cytosol] (Homo sapiens)
Regulator
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
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TRIF:activated TLR3/TLR4 complex recruits RIP1 (Mus musculus)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Rattus norvegicus)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Sus scrofa)
viral dsRNA:TRL3:TICAM1 activates RIP1 (Gallus gallus)
Authored
de Bono, B  (2005-08-16)
Reviewed
Gay, NJ  (2006-04-24)
Gillespie, ME  (2010-11-30)
Fitzgerald, KA  (2012-11-13)
Created
de Bono, B  (2005-11-22)
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