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NGF processing
Stable Identifier
R-HSA-167060
DOI
10.3180/REACT_11062.2
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Expression and Processing of Neurotrophins (Homo sapiens)
NGF processing (Homo sapiens)
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All neurotrophins (NTs) are generated as pre-pro-neurotrophin precursors. The signal peptide is cleaved off as NT is associated with the endoplasmic reticulum (ER). The resulting pro-NT can form a homodimer spontaneously which then transits to the Golgi apparatus and then onto the trans-Golgi network (TGN). Resident protein convertases (PCs) can cleave off the pro-sequence and mature NT is is targeted to constitutively released vesicles. The pro-NT form can also be released to the extracellular region.
Literature References
PubMed ID
Title
Journal
Year
12787574
Neurotrophin secretion: current facts and future prospects
Lessmann, V
,
Gottmann, K
,
Malcangio, M
Prog Neurobiol
2003
Participants
Events
The signal peptide is excised from beta-NGF pre-pro-precursor
(Homo sapiens)
pro-beta-NGF dimerizes
(Homo sapiens)
pro-beta-NGF homodimer transits to the golgi apparatus
(Homo sapiens)
Part of pro-beta-NGF is processed to mature beta-NGF
(Homo sapiens)
Pro-beta-NGF and mature beta-NGF are secreted
(Homo sapiens)
Participates
as an event of
Expression and Processing of Neurotrophins (Homo sapiens)
Event Information
Go Biological Process
nerve growth factor processing (0032455)
Orthologous Events
NGF processing (Bos taurus)
NGF processing (Canis familiaris)
NGF processing (Danio rerio)
NGF processing (Gallus gallus)
NGF processing (Mus musculus)
NGF processing (Rattus norvegicus)
NGF processing (Sus scrofa)
NGF processing (Xenopus tropicalis)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
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