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Pro-beta-NGF and mature beta-NGF are secreted
Stable Identifier
R-HSA-187035
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
,
Golgi lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Expression and Processing of Neurotrophins (Homo sapiens)
NGF processing (Homo sapiens)
Pro-beta-NGF and mature beta-NGF are secreted (Homo sapiens)
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Both mature neurotrophin and pro-neurotrophin are released extracellularly and are biologically active. The precursor proNGF, instead of mNGF (mature NGF), is the molecular form preferentially released by neurons in an activity-dependent manner. Neurotrophins are secreted in low amounts from several tissues, mainly from target tissues of innervating neurons. In the nervous system, they are secreted by neurons, astrocytes and microglia. Neurotrophin secretion can be both constitutive and regulated. Constitutive release is observed in cells lacking a regulated pathway, and additional stimulus-dependent regulated secretion is evident in those cells where this route is available. Secretion is regulated by a number of stimuli, including neurotrophins themselves. In neurons, regulated secretion appears to be the prevalent pathway. NGF is secreted from the cell soma and the dendrites, while it is unclear whether it can also be secreted by axons. Constitutive secretion of NGF is observed only from the soma and the most proximal dendrites. Similar considerations hold for the other neurotrophins as well.
Literature References
PubMed ID
Title
Journal
Year
12787574
Neurotrophin secretion: current facts and future prospects
Lessmann, V
,
Gottmann, K
,
Malcangio, M
Prog Neurobiol
2003
Participants
Input
mature beta-NGF homodimer [Golgi lumen]
(Homo sapiens)
pro-beta-NGF homodimer [Golgi lumen]
(Homo sapiens)
Output
mature beta-NGF homodimer [extracellular region]
(Homo sapiens)
pro-beta-NGF homodimer [extracellular region]
(Homo sapiens)
Participates
as an event of
NGF processing (Homo sapiens)
Orthologous Events
Pro-beta-NGF and mature beta-NGF are secreted (Bos taurus)
Pro-beta-NGF and mature beta-NGF are secreted (Canis familiaris)
Pro-beta-NGF and mature beta-NGF are secreted (Danio rerio)
Pro-beta-NGF and mature beta-NGF are secreted (Gallus gallus)
Pro-beta-NGF and mature beta-NGF are secreted (Mus musculus)
Pro-beta-NGF and mature beta-NGF are secreted (Rattus norvegicus)
Pro-beta-NGF and mature beta-NGF are secreted (Sus scrofa)
Pro-beta-NGF and mature beta-NGF are secreted (Xenopus tropicalis)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Created
Jassal, B (2006-09-07)
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