pro-beta-NGF dimerizes

Stable Identifier
R-HSA-167047
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The pro-neurotrophin (pro-NGF: 27 kDa) spontaneously forms stable, non-covalent dimers directly in the ER. The homodimer is associated by noncovalent forces, with an equilibrium dissociation constant of 10 pM. The neurotrophin pro- domain is important for proper folding and intracellular sorting. Heterodimers of different neurotrophin monomers can also be generated at the ER.

Participants
Participant Of
hasEvent
Inferred From
Authored
Reviewed
Created