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pro-beta-NGF dimerizes
Stable Identifier
R-HSA-167047
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Expression and Processing of Neurotrophins (Homo sapiens)
NGF processing (Homo sapiens)
pro-beta-NGF dimerizes (Homo sapiens)
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The pro-neurotrophin (pro-NGF: 27 kDa) spontaneously forms stable, non-covalent dimers directly in the ER. The homodimer is associated by noncovalent forces, with an equilibrium dissociation constant of 10 pM. The neurotrophin pro- domain is important for proper folding and intracellular sorting. Heterodimers of different neurotrophin monomers can also be generated at the ER.
Participants
Input
x 2
NGF(19-241) [endoplasmic reticulum lumen]
(Homo sapiens)
Output
pro-beta-NGF homodimer [endoplasmic reticulum lumen]
(Homo sapiens)
Participates
as an event of
NGF processing (Homo sapiens)
Inferred From
pro-NGF dimerizes (Mus musculus)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
© 2024
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