Reactome | MASP2-1 dimer [extracellular region]

MASP2-1 dimer [extracellular region]

Stable Identifier

R-HSA-166694

Type

Complex

Species

Homo sapiens

Compartment

extracellular region

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 N binds MASP2 (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        N:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MASP2-1 dimer [extracellular region] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
11337510	Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation. Wallis, R, Chen, CB	J Biol Chem	2001

Participants

components

x 2 MASP2-1 [extracellular region] (Homo sapiens)

Participates

as a component of

Inferred To

MASP2-1 dimer [extracellular region] (Bos taurus)

MASP2-1 dimer [extracellular region] (Canis familiaris)

MASP2-1 dimer [extracellular region] (Gallus gallus)

MASP2-1 dimer [extracellular region] (Mus musculus)

MASP2-1 dimer [extracellular region] (Rattus norvegicus)

MASP2-1 dimer [extracellular region] (Sus scrofa)

MASP2-1 dimer [extracellular region] (Xenopus tropicalis)

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