Reactome | MASP2-1 [extracellular region]

MASP2-1 [extracellular region]

Stable Identifier

R-HSA-166689

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

MASP-2, MASP2 isoform 1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 N binds MASP2 (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MASP2-1 [extracellular region] (Homo sapiens)
        
        N:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MASP2-1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00187-1 MASP2

Gene Names

MASP2

Participates

as a component of

MASP2-1 dimer [extracellular region] (Homo sapiens)

Other forms of this molecule

MASP2-1(445-686) [extracellular region]

MASP2-1(16-444) [extracellular region]

Inferred To

MASP2-1 [extracellular region] (Bos taurus)

MASP2-1 [extracellular region] (Canis familiaris)

MASP2-1 [extracellular region] (Gallus gallus)

MASP2-1 [extracellular region] (Mus musculus)

MASP2-1 [extracellular region] (Rattus norvegicus)

MASP2-1 [extracellular region] (Sus scrofa)

MASP2-1 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_631947.1, NP_006601.2

ENSEMBL

ENST00000400897, ENSP00000383691, ENSG00000009724, ENST00000400898, ENSP00000383690

OpenTargets

ENSG00000009724

IntEnz

3.4.21.104

GeneCards

MASP2

HPA

ENSG00000009724-MASP2

PRO

O00187

Pharos - Targets

O00187

GlyGen

O00187

Orphanet

MASP2

HMDB Protein

HMDBP07788

PDB

3TVJ, 5JPM, 1ZJK, 1SZB, 1Q3X

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
mannan [ChEBI:28808]	1	alpha-mannan [plasma membrane] (R-ALL-5621136)	0.75	4
UniProt:P05155 SERPING1	20	SERPING1 L177P [endoplasmic reticulum lumen] (R-HSA-9650574) SERPING1 R400C [endoplasmic reticulum lumen] (R-HSA-9650511) SERPING1 V288E [endoplasmic reticulum lumen] (R-HSA-9650415) SERPING1 G184_P228del [endoplasmic reticulum lumen] (R-HSA-9650472) SERPING1 F236S [endoplasmic reticulum lumen] (R-HSA-9650538) SERPING1 T189N [endoplasmic reticulum lumen] (R-HSA-9650346) SERPING1 P476L [endoplasmic reticulum lumen] (R-HSA-9650563) SERPING1 G184R [endoplasmic reticulum lumen] (R-HSA-9650424) SERPING1 P489R [endoplasmic reticulum lumen] (R-HSA-9650330) SERPING1 S170P [endoplasmic reticulum lumen] (R-HSA-9650362) SERPING1 S280_P282del [endoplasmic reticulum lumen] (R-HSA-9650522) SERPING1 V473M [endoplasmic reticulum lumen] (R-HSA-9650331) SERPING1 N291H [endoplasmic reticulum lumen] (R-HSA-9650545) SERPING1 Q484* [endoplasmic reticulum lumen] (R-HSA-9650410) SERPING1 A2_M53del [endoplasmic reticulum lumen] (R-HSA-9651435) SERPING1 W482* [endoplasmic reticulum lumen] (R-HSA-9650502) SERPING1 Q338* [endoplasmic reticulum lumen] (R-HSA-9651424) SERPING1 I196N [endoplasmic reticulum lumen] (R-HSA-9651390) SERPING1 S36Ffs*21 [endoplasmic reticulum lumen] (R-HSA-9651423) SERPING1 G184E [endoplasmic reticulum lumen] (R-HSA-9650527)	0.676	3