Reactome | MASP2-1 [extracellular region]

MASP2-1 [extracellular region]

Stable Identifier

R-HSA-166689

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

MASP-2, MASP2 isoform 1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - SARS-CoV Infections (Homo sapiens)
    - SARS-CoV-2 Infection (Homo sapiens)
      - SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 N binds MASP2 (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MASP2-1 [extracellular region] (Homo sapiens)
        
        N:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MASP2-1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00187-1 MASP2

Gene Names

MASP2

Other Identifiers

0002480136

0006840017

0007000706

10747

11735645_a_at

11740562_at

16681595

207041_PM_at

207041_at

210798_3p_x_at

210798_PM_x_at

210798_x_at

2396419

2396420

2396421

2396422

2396423

2396427

2396430

2396431

2396432

2396434

2396438

2396440

2396442

2396444

2396445

2396447

37514_s_at

37515_at

7912361

A_23_P301971

A_33_P3247571

A_33_P3307990

GE81659

GO:0001855

GO:0001867

GO:0002376

GO:0003674

GO:0004252

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0006508

GO:0006950

GO:0006958

GO:0008150

GO:0008233

GO:0008236

GO:0016787

GO:0042802

GO:0043167

GO:0043226

GO:0045087

GO:0046872

GO:0048306

GO:0070062

HMNXSV003048003

ILMN_1691464

ILMN_1709408

ILMN_1727723

ILMN_1735260

PH_hs_0006621

TC01002194.hg

TC01005262.hg

g5002493_3p_a_at

g5002493_3p_s_at

g5002493_3p_x_at

g5729914_3p_at

Participates

as a component of

MASP2-1 dimer [extracellular region] (Homo sapiens)

Other forms of this molecule

MASP2-1(445-686) [extracellular region]

MASP2-1(16-444) [extracellular region]

Inferred To

MASP2 [extracellular region] (Bos taurus)

MASP2 [extracellular region] (Canis familiaris)

MASP2 [extracellular region] (Gallus gallus)

MASP2 [extracellular region] (Sus scrofa)

masp2 [extracellular region] (Danio rerio)

masp2 [extracellular region] (Xenopus tropicalis)

Masp2 [extracellular region] (Mus musculus)

Masp2 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_006601.2, NP_631947.1

OpenTargets

ENSG00000009724

IntEnz

3.4.21.104

GeneCards

O00187

HPA

ENSG00000009724-MASP2

Ensembl

ENSP00000383690, ENSG00000009724, ENSP00000383691, ENST00000400897, ENST00000400898

PRO

O00187

Pharos - Targets

O00187

Orphanet

22036

HMDB Protein

HMDBP07788

PDB

1SZB, 1ZJK, 1Q3X, 4FXG, 5JPM, 3TVJ

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
mannan [ChEBI:28808]	1	alpha-mannan [plasma membrane] (R-ALL-5621136)	0.75	4
UniProt:P05155 SERPING1	20	SERPING1 [platelet alpha granule lumen] (R-HSA-139868) SERPING1 L177P [endoplasmic reticulum lumen] (R-HSA-9650574) SERPING1 R400C [endoplasmic reticulum lumen] (R-HSA-9650511) SERPING1 V288E [endoplasmic reticulum lumen] (R-HSA-9650415) SERPING1 G184_P228del [endoplasmic reticulum lumen] (R-HSA-9650472) SERPING1 F236S [endoplasmic reticulum lumen] (R-HSA-9650538) SERPING1 T189N [endoplasmic reticulum lumen] (R-HSA-9650346) SERPING1 P476L [endoplasmic reticulum lumen] (R-HSA-9650563) SERPING1 G184R [endoplasmic reticulum lumen] (R-HSA-9650424) SERPING1 P489R [endoplasmic reticulum lumen] (R-HSA-9650330) SERPING1 S170P [endoplasmic reticulum lumen] (R-HSA-9650362) SERPING1 S280_P282del [endoplasmic reticulum lumen] (R-HSA-9650522) SERPING1 V473M [endoplasmic reticulum lumen] (R-HSA-9650331) SERPING1 N291H [endoplasmic reticulum lumen] (R-HSA-9650545) SERPING1 Q484* [endoplasmic reticulum lumen] (R-HSA-9650410) SERPING1 A2_M53del [endoplasmic reticulum lumen] (R-HSA-9651435) SERPING1 W482* [endoplasmic reticulum lumen] (R-HSA-9650502) SERPING1 Q338* [endoplasmic reticulum lumen] (R-HSA-9651424) SERPING1 I196N [endoplasmic reticulum lumen] (R-HSA-9651390) SERPING1 S36Ffs*21 [endoplasmic reticulum lumen] (R-HSA-9651423)	0.676	3

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