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MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region]
Stable Identifier
R-HSA-166710
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
SARS-CoV-2 N binds MASP2 (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Creation of C4 and C2 activators (Homo sapiens)
Lectin pathway of complement activation (Homo sapiens)
Activation of MASPs (Homo sapiens)
MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11337510
Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation.
Wallis, R
,
Chen, CB
J Biol Chem
2001
Participants
components
MASP1 dimer [extracellular region]
(Homo sapiens)
MASP2-1 dimer [extracellular region]
(Homo sapiens)
MBL2 dodecamer [extracellular region]
(Homo sapiens)
Participates
as an input of
SARS-CoV-2 N binds MASP2 (Homo sapiens)
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)
as a component of
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
Inferred To
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region]
(Bos taurus)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region]
(Gallus gallus)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region]
(Mus musculus)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region]
(Rattus norvegicus)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region]
(Sus scrofa)
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