PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine

Stable Identifier
R-HSA-1655443
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
3-sulfino-L-alanine + H(+) => CO2 + hypotaurine
ReviewStatus
5/5
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PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine
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Cysteine sulfinic acid decarboxylase (CSAD) mediates the decarboxylation of 3-sulfinoalanine to produce hypotaurine. CSAD functions as a homodimer and requires pyridoxal phosphate as a cofactor (Winge et al. 2015). Purification, characterisation and activity of CSAD has been determined from rat liver (Guion-Rain et al. 1975).
Literature References
PubMed ID Title Journal Year
26327310 Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression

Winge, I, Teigen, K, Fossbakk, A, Mahootchi, E, Kleppe, R, Sköldberg, F, Kämpe, O, Haavik, J

Neurochem Int 2015
236774 Rat liver cysteine sulfinate decarboxylase: purification, new appraisal of the molecular weight and determination of catalytic properties

Guion-Rain, M-C, Portemer, C, Chatagner, F

Biochim Biophys Acta 1975
Participants
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Output
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as an event of
Catalyst Activity

sulfinoalanine decarboxylase activity of PXKLP-K305-CSAD dimer [cytosol]

Physical Entity
PXKLP-K305-CSAD dimer [cytosol] (Homo sapiens)
Activity
sulfinoalanine decarboxylase activity (GO:0004782)
Inferred From
PXLP-K305-Csad decarboxylates 3-sulfinoalanine to hypotaurine (Rattus norvegicus)
Cross References
RHEA
Authored
Jassal, B  (2011-10-12)
Reviewed
D'Eustachio, P  (2011-10-13)
Hill, DP  (2025-02-25)
Created
Jassal, B  (2011-10-12)
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