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Degradation of cysteine and homocysteine
Stable Identifier
R-HSA-1614558
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Sulfur amino acid metabolism (Homo sapiens)
Degradation of cysteine and homocysteine (Homo sapiens)
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While in humans excess methionine is converted to homocysteine, homocysteine and its transsulfuration product cysteine can be degraded to several end products, two of which, taurine and hydrogen sulfide, have uses in other biological processes (Stipanuk & Ueki 2011).
Literature References
PubMed ID
Title
Journal
Year
20162368
Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur
Ueki, I
,
Stipanuk, MH
J Inherit Metab Dis
2011
Participants
Events
Homocysteine is degraded to oxobutanoate and H2S
(Homo sapiens)
Cysteine is degraded to pyruvate and H2S
(Homo sapiens)
CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine
(Homo sapiens)
PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine
(Homo sapiens)
ADO oxidises 2AET to HTAU
(Homo sapiens)
PXLP-K333-GADL1 decarboxylates CSA to HTAU
(Homo sapiens)
FMO1:FAD oxidizes HTAU to TAU
(Homo sapiens)
Excess homocysteine yields homolanthionine and H2S
(Homo sapiens)
Excess cysteine yields lanthionine and H2S
(Homo sapiens)
GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu
(Homo sapiens)
MPST transfers sulfur atom from 3MPYR to form CysS248-MPST
(Homo sapiens)
MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST
(Homo sapiens)
MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR
(Homo sapiens)
MPST transfers sulfur from 3MPYR to HCN to form HSCN
(Homo sapiens)
MPST transfers sulfur from sulfanegen to HCN to form HSCN
(Homo sapiens)
TST transfers sulfur from S2O3(2-) to HCN to form HSCN
(Homo sapiens)
Sulfide oxidation to sulfate
(Homo sapiens)
Participates
as an event of
Sulfur amino acid metabolism (Homo sapiens)
Event Information
Go Biological Process
sulfur amino acid catabolic process (0000098)
Orthologous Events
Degradation of cysteine and homocysteine (Bos taurus)
Degradation of cysteine and homocysteine (Caenorhabditis elegans)
Degradation of cysteine and homocysteine (Canis familiaris)
Degradation of cysteine and homocysteine (Danio rerio)
Degradation of cysteine and homocysteine (Dictyostelium discoideum)
Degradation of cysteine and homocysteine (Drosophila melanogaster)
Degradation of cysteine and homocysteine (Gallus gallus)
Degradation of cysteine and homocysteine (Mus musculus)
Degradation of cysteine and homocysteine (Plasmodium falciparum)
Degradation of cysteine and homocysteine (Rattus norvegicus)
Degradation of cysteine and homocysteine (Saccharomyces cerevisiae)
Degradation of cysteine and homocysteine (Schizosaccharomyces pombe)
Degradation of cysteine and homocysteine (Sus scrofa)
Degradation of cysteine and homocysteine (Xenopus tropicalis)
Authored
Stephan, R (2010-10-24)
Reviewed
D'Eustachio, P (2011-10-13)
Hill, DP (2025-02-25)
Created
Jassal, B (2011-09-29)
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