Reactome | NDUFB8 [mitochondrial inner membrane]

NDUFB8 [mitochondrial inner membrane]

Stable Identifier

R-HSA-163938

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase ASHI subunit

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Complex I biogenesis (Homo sapiens)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95169 NDUFB8

Gene Names

NDUFB8

Chain

transit peptide:1-28, chain:29-186

Reference Genes

BioGPS Gene:4714 NDUFB8

COSMIC (genes):NDUFB8 NDUFB8

CTD Gene:4714 NDUFB8

dbSNP Gene:4714 NDUFB8

ENSEMBL:ENSG00000166136 NDUFB8

HGNC:7703 NDUFB8

KEGG Gene (Homo sapiens):4714 NDUFB8

Monarch:4714 NDUFB8

NCBI Gene:4714 NDUFB8

OMIM:602140 NDUFB8

UCSC:O95169 NDUFB8

Reference Transcript

Other Identifiers

0000430408

11716414_a_at

11716415_s_at

201226_at

201227_s_at

214241_at

32774_at

3303531

3303532

3303533

3303534

3303537

3303538

3303539

3303540

3303541

3303542

3543747

3729290

3886

4714

5XTC

5XTD

5XTH

5XTI

7935810

A_24_P346886

A_33_P3384721

AAD05422

AAD27761

AAH00466

AAH19276

AAP97239

AF044958

AF077028

AF115968

AK289579

AK295867

AL080056

AL133352

BAF82268

BAG58666

BC000466

BC019276

BI602529

CAB45691

CAB46274

CAG38521

CCDS65916

CCDS65917

CCDS7497

CH471066

CR533490

E9PIZ8

EAW49819

EAW49820

ENSG00000166136

ENSP00000299166

ENSP00000359344

ENSP00000359346

ENST00000299166

ENST00000299166.8

ENST00000370320

ENST00000370320.4

ENST00000370322

ENST00000370322.5

EntrezGene:4714

EntrezGene:NDUFB8

g4826853_3p_a_at

GE80107

GE86517

GO:0003674

GO:0003954

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005743

GO:0005747

GO:0005759

GO:0005783

GO:0006091

GO:0006120

GO:0007005

GO:0008137

GO:0008150

GO:0016020

GO:0016021

GO:0016491

GO:0022607

GO:0032981

GO:0032991

GO:0043226

GO:0055114

GO:0065003

GO:0070469

HGNC:7703

HPA003886

ILMN_1661170

IPR008699

IPR016551

MIM:602140

MIM:618252

NDUFB8

NDUFB8-201

NDUFB8-202

NDUFB8-203

NM_001284367

NM_001284368

NM_005004

NP_001271296

NP_001271297

NP_004995

PF05821

UPI000013005D

UPI00001F955E

UPI000045880F

Y18944

Participant Of

hasMember

Cargo of TIMM23 SORT [mitochondrial inner membrane]

hasComponent

HP subcomplex [mitochondrial inner membrane]

Other forms of this molecule

NDUFB8(1-186) [mitochondrial intermembrane space]

NDUFB8(1-28) [mitochondrial matrix]

NDUFB8(1-186) [mitochondrial inner membrane]

Inferred To

Ghost homologue of NDUFB8 [mitochondrial inner membrane] (Xenopus tropicalis)

NDUFB8 [mitochondrial inner membrane] (Bos taurus)

NDUFB8 [mitochondrial inner membrane] (Caenorhabditis elegans)

NDUFB8 [mitochondrial inner membrane] (Canis familiaris)

NDUFB8 [mitochondrial inner membrane] (Danio rerio)

NDUFB8 [mitochondrial inner membrane] (Drosophila melanogaster)

NDUFB8 [mitochondrial inner membrane] (Gallus gallus)

NDUFB8 [mitochondrial inner membrane] (Mus musculus)

NDUFB8 [mitochondrial inner membrane] (Rattus norvegicus)

NDUFB8 [mitochondrial inner membrane] (Sus scrofa)

Cross References

RefSeq

NP_004995.1, NP_001271297.1, NP_001271296.1

OpenTargets

ENSG00000166136

GeneCards

O95169

PRO

O95169

Orphanet

24749

HMDB Protein

HMDBP00200

PDB

5XTC, 5XTI, 5XTD, 5XTH

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75489 NDUFS3	1	NDUFS3 [mitochondrial matrix] (R-HSA-163927)	0.643	4