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NDUFB8 [mitochondrial inner membrane]
Stable Identifier
R-HSA-163938
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
NADH-ubiquinone oxidoreductase ASHI subunit
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
Protein localization (Homo sapiens)
Mitochondrial protein import (Homo sapiens)
MPP cleaves targeting peptide (presequence) of inner membrane precursors (Homo sapiens)
TIMM23 SORT:Cargo [mitochondrial inner membrane] (Homo sapiens)
Cargo of TIMM23 SORT [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
TIMM23 SORT inserts proteins into inner membrane (Homo sapiens)
Cargo of TIMM23 SORT [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
TIMM23 SORT:Cargo [mitochondrial inner membrane] (Homo sapiens)
Cargo of TIMM23 SORT [mitochondrial inner membrane] (Homo sapiens)
NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95169 NDUFB8
Gene Names
NDUFB8
Chain
transit peptide:1-28, chain:29-186
Reference Genes
BioGPS Gene:4714 NDUFB8
COSMIC (genes):NDUFB8 NDUFB8
CTD Gene:4714 NDUFB8
dbSNP Gene:4714 NDUFB8
ENSEMBL:ENSG00000166136.16 NDUFB8
HGNC:7703 NDUFB8
KEGG Gene (Homo sapiens):4714 NDUFB8
Monarch:4714 NDUFB8
NCBI Gene:4714 NDUFB8
OMIM:602140 NDUFB8
UCSC:O95169 NDUFB8
Reference Transcript
RefSeq:NM_001284367.1 NDUFB8
RefSeq:NM_005004.3 NDUFB8
RefSeq:NM_001284368.1 NDUFB8
Other Identifiers
0000430408
11716414_a_at
11716415_s_at
201226_PM_at
201226_at
201227_PM_s_at
201227_s_at
214241_PM_at
214241_at
32774_at
3303531
3303532
3303533
3303534
3303537
3303538
3303539
3303540
3303541
3303542
3543747
3729290
4714
7935810
A_24_P346886
A_33_P3384721
GE80107
GE86517
GO:0005215
GO:0005622
GO:0005737
GO:0005739
GO:0005743
GO:0005747
GO:0005759
GO:0005783
GO:0006091
GO:0006120
GO:0007005
GO:0008137
GO:0009060
GO:0016020
GO:0016021
GO:0016491
GO:0032981
GO:0032991
GO:0042776
GO:0043226
GO:0055086
GO:0065003
GO:0070469
GO:1901135
HMNXSV003002485
ILMN_1661170
g4826853_3p_a_at
Participates
as a member of
Cargo of TIMM23 SORT [mitochondrial inner membrane] (Homo sapiens)
as a component of
HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
Other forms of this molecule
NDUFB8(1-186) [mitochondrial intermembrane space]
NDUFB8(1-28) [mitochondrial matrix]
NDUFB8(1-186) [mitochondrial inner membrane]
Inferred To
Ghost homologue of NDUFB8 [mitochondrial inner membrane]
(Xenopus tropicalis)
ND-ASHI [mitochondrial inner membrane]
(Drosophila melanogaster)
NDUFB8 [mitochondrial inner membrane]
(Bos taurus)
NDUFB8 [mitochondrial inner membrane]
(Caenorhabditis elegans)
NDUFB8 [mitochondrial inner membrane]
(Canis familiaris)
NDUFB8 [mitochondrial inner membrane]
(Danio rerio)
NDUFB8 [mitochondrial inner membrane]
(Gallus gallus)
NDUFB8 [mitochondrial inner membrane]
(Sus scrofa)
Ndufb8 [mitochondrial inner membrane]
(Mus musculus)
Ndufb8 [mitochondrial inner membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_004995.1
,
NP_001271296.1
,
NP_001271297.1
OpenTargets
ENSG00000166136
HPA
ENSG00000166136-NDUFB8
GeneCards
O95169
Ensembl
ENSP00000359346
,
ENSP00000299166
,
ENSG00000166136
,
ENST00000370320
,
ENST00000370322
,
ENST00000299166
,
ENSP00000359344
PRO
O95169
Pharos - Targets
O95169
Orphanet
24749
PDB
5XTI
,
5XTC
,
5XTH
,
5XTD
HMDB Protein
HMDBP00200
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.643
4
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