Reactome | NDUFB8 [mitochondrial inner membrane]

NDUFB8 [mitochondrial inner membrane]

Stable Identifier

R-HSA-163938

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase ASHI subunit

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Complex I biogenesis (Homo sapiens)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFB8 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95169 NDUFB8

Gene Names

NDUFB8

Chain

transit peptide:1-28, chain:29-186

Reference Genes

BioGPS Gene:4714 NDUFB8

COSMIC (genes):NDUFB8 NDUFB8

CTD Gene:4714 NDUFB8

dbSNP Gene:4714 NDUFB8

ENSEMBL:ENSG00000166136.16 NDUFB8

HGNC:7703 NDUFB8

KEGG Gene (Homo sapiens):4714 NDUFB8

Monarch:4714 NDUFB8

NCBI Gene:4714 NDUFB8

OMIM:602140 NDUFB8

UCSC:O95169 NDUFB8

Reference Transcript

Other Identifiers

0000430408

11716414_a_at

11716415_s_at

201226_PM_at

201226_at

201227_PM_s_at

201227_s_at

214241_PM_at

214241_at

32774_at

3303531

3303532

3303533

3303534

3303537

3303538

3303539

3303540

3303541

3303542

3543747

3729290

4714

7935810

A_24_P346886

A_33_P3384721

GE80107

GE86517

GO:0005215

GO:0005622

GO:0005737

GO:0005739

GO:0005743

GO:0005747

GO:0005759

GO:0005783

GO:0006091

GO:0006120

GO:0007005

GO:0008137

GO:0009060

GO:0016020

GO:0016021

GO:0016491

GO:0032981

GO:0032991

GO:0042776

GO:0043226

GO:0055086

GO:0065003

GO:0070469

GO:1901135

HMNXSV003002485

ILMN_1661170

g4826853_3p_a_at

Participates

as a member of

Cargo of TIMM23 SORT [mitochondrial inner membrane] (Homo sapiens)

as a component of

HP subcomplex [mitochondrial inner membrane] (Homo sapiens)

Other forms of this molecule

NDUFB8(1-186) [mitochondrial intermembrane space]

NDUFB8(1-28) [mitochondrial matrix]

NDUFB8(1-186) [mitochondrial inner membrane]

Inferred To

Ghost homologue of NDUFB8 [mitochondrial inner membrane] (Xenopus tropicalis)

ND-ASHI [mitochondrial inner membrane] (Drosophila melanogaster)

NDUFB8 [mitochondrial inner membrane] (Bos taurus)

NDUFB8 [mitochondrial inner membrane] (Caenorhabditis elegans)

NDUFB8 [mitochondrial inner membrane] (Canis familiaris)

NDUFB8 [mitochondrial inner membrane] (Danio rerio)

NDUFB8 [mitochondrial inner membrane] (Gallus gallus)

NDUFB8 [mitochondrial inner membrane] (Sus scrofa)

Ndufb8 [mitochondrial inner membrane] (Mus musculus)

Ndufb8 [mitochondrial inner membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_004995.1, NP_001271296.1, NP_001271297.1

OpenTargets

ENSG00000166136

HPA

ENSG00000166136-NDUFB8

GeneCards

O95169

Ensembl

ENSP00000359346, ENSP00000299166, ENSG00000166136, ENST00000370320, ENST00000370322, ENST00000299166, ENSP00000359344

PRO

O95169

Pharos - Targets

O95169

Orphanet

24749

PDB

5XTI, 5XTC, 5XTH, 5XTD

HMDB Protein

HMDBP00200

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.643	4

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