Reactome | AMPK inhibits chREBP transcriptional activation activity

AMPK inhibits chREBP transcriptional activation activity

Stable Identifier

R-HSA-163680

DOI

10.3180/R-HSA-163680.6

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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AMPK inhibits chREBP transcriptional activation activity

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AMP-activated protein kinase (AMPK) is a sensor of cellular energy levels. A high cellular ratio of AMP:ATP triggers the phosphorylation and activation of AMPK. Activated AMPK in turn phosphorylates a wide array of target proteins, as shown in the figure below (reproduced from (Hardie et al. 2003), with the permission of D.G. Hardie). These targets include ChREBP (Carbohydrate Response Element Binding Protein), whose inactivation by phosphorylation reduces transcription of key enzymes of the glycolytic and lipogenic pathways.

Literature References

PubMed ID	Title	Journal	Year
12829246	Management of cellular energy by the AMP-activated protein kinase system Hardie, DG, Scott, JW, Pan, DA, Hudson, ER	FEBS Lett	2003
11724780	Mechanism for fatty acid sparing effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase Kawaguchi, T, Osatomi, K, Yamashita, H, Kabashima, T, Uyeda, K	J Biol Chem	2002
15509864	The AMP-activated protein kinase pathway--new players upstream and downstream Hardie, DG	J Cell Sci	2004
10698692	Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding Cheung, PC, Salt, IP, Davies, SP, Hardie, DG, Carling, D	Biochem J	2000